La Padula Simone, Pensato Rosita, Errico Concetta, D'Andrea Francesco, Persichetti Paolo, Chesné Christophe, Jamin Agnes, Ben Mosbah Ismail, Toia Francesca, Cordova Adriana, Meningaud Jean Paul, Hersant Barbara
Department of Plastic and Reconstructive Surgery, Università degli studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, Italy.
Department of Plastic, Reconstructive and Maxillo facial Surgery, Henri Mondor Hospital, University Paris XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.
Aesthetic Plast Surg. 2025 Apr;49(7):2076-2084. doi: 10.1007/s00266-024-04560-7. Epub 2024 Dec 3.
Striae distensae (SD) appear clinically as parallel striae, lying perpendicular to the tension lines of the skin. SD evolve into two clinical phases, an initial inflammatory phase in which they are called "striae rubrae" (SR) and a chronic phase in which they are called striae albae (SA). This study investigates the synergistic effect of nanofat and platelet-rich plasma (PRP) injections on collagen production in fibroblasts derived from SA (SAF).
A prospective, randomized single-blind study was conducted in fifty women presenting with SA in the abdominal region who had voluntarily sought a conventional abdominoplasty procedure and accepted to test an autologous treatment for their SDs. SA were treated using: PrP 10 ml; PrP 2ml (20%) + nanofat 8ml (80%); nanofat 10ml. Following the abdominal dermolipectomy, biopsies from treated and untreated SDs were taken and analyzed for type I collagen quantification. Results were processed through statistical analysis models using the Student's t test.
Collagen concentration in untreated SA biopsies was significantly lower than in healthy skin. Both PRP and nanofat treatments significantly increased collagen biosynthesis compared to controls, with the combined PRP-nanofat treatment showing the highest increase in collagen levels (p < 0.0001). A superior clinical improvement was observed in the areas that received the combined treatment of PRP and nanofat (p = 0.001).
Our findings indicate that both PRP and nanofat treatments effectively enhance collagen production in SA, with the combined PRP-nanofat treatment showing a synergistic effect. This combined therapy holds promise for effectively treating SA, providing a new potential treatment avenue for SMs and similar skin conditions. Further studies are needed to validate these results and explore clinical applications.
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膨胀纹（SD）在临床上表现为与皮肤张力线垂直的平行条纹。SD 会发展为两个临床阶段，初始炎症阶段称为“红色膨胀纹”（SR），慢性阶段称为白色膨胀纹（SA）。本研究调查了纳米脂肪和富血小板血浆（PRP）注射对源自 SA 的成纤维细胞（SAF）中胶原蛋白生成的协同作用。
对 50 名腹部有 SA 且自愿寻求传统腹部整形手术并同意测试其 SD 自体治疗方法的女性进行了一项前瞻性、随机单盲研究。SA 采用以下方法治疗：10ml PRP；2ml PRP（20%）+8ml 纳米脂肪（80%）；10ml 纳米脂肪。腹部皮肤切除术后，取自治疗和未治疗的 SD 的活检组织并分析 I 型胶原蛋白定量。结果通过使用学生 t 检验的统计分析模型进行处理。
未治疗的 SA 活检组织中的胶原蛋白浓度显著低于健康皮肤。与对照组相比，PRP 和纳米脂肪治疗均显著增加了胶原蛋白生物合成，PRP - 纳米脂肪联合治疗显示胶原蛋白水平增加最高（p < 0.0001）。在接受 PRP 和纳米脂肪联合治疗的区域观察到了更好的临床改善（p = 0.001）。
我们的研究结果表明，PRP 和纳米脂肪治疗均能有效增强 SA 中的胶原蛋白生成，PRP - 纳米脂肪联合治疗显示出协同作用。这种联合疗法有望有效治疗 SA，为膨胀纹及类似皮肤状况提供了一种新的潜在治疗途径。需要进一步研究来验证这些结果并探索临床应用。
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