Lv Yuxin, Liu Li, Luo Xiaoyan
Department of Dermatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Lasers Med Sci. 2025 Mar 18;40(1):146. doi: 10.1007/s10103-025-04401-2.
Pyogenic Granuloma (PG) is a benign vascular tumor with multiple treatment; current therapies mainly focus on laser therapy but its' use in children was rarely been reported. This retrospective study aimed to analyze the effectiveness and safety of the 1064 nm long-pulsed Nd: YAG laser for treating PG among children attending our Dermatology Laser Clinic to take laser therapy. The researchers collected data of 30 Chinese pediatric PG patients treated with 1064 nm long-pulsed Nd: YAG laser with fluences of 85-130 J/cm and pulse width of 10-40 and pulse of 1-4 at one-month intervals. Total treatment ranged from one to two sessions. A assessment of clinical efficacy was made by two physicians through measuring the long and short diameters of PG in standard photos to compute the changes in the PG volume. Based on the pretreatment and post-treatment photos, a 5-point grading scale was used for the evaluation of pigment clearance: 5 for complete (95-100%), 4 for excellent (75-94%), 3 for good (50-74%), 2 for fair (25-49%), and 1 for poor (0-24%). Adverse reactions such as bleeding, scar and pigmentation were recorded during the follow-up visit after treatment. Among these patients, 28 recovered after a single treatment, and 2 received two treatments. After the first laser treatment, there was a significant reduction in grading scores(p < 0.0001), accompanied by a notable improvement in physician visual evaluation. There was recurrence-free during 6 months of follow-up in all patients. Only 1 patient was observed with a scar. Post-inflammatory hyperpigmentation after treatment was observed in 2 patients which improved within 3 months. Hypopigmentation was not found after treatment. The 1064 nm long-pulsed Nd: YAG laser is an effective and safe approach for treating PG in children.
化脓性肉芽肿（PG）是一种有多种治疗方法的良性血管肿瘤；目前的治疗主要集中在激光治疗，但很少有其在儿童中应用的报道。这项回顾性研究旨在分析1064纳米长脉冲Nd:YAG激光治疗在我们皮肤科激光诊所接受激光治疗的儿童PG的有效性和安全性。研究人员收集了30例接受1064纳米长脉冲Nd:YAG激光治疗的中国儿童PG患者的数据，激光能量密度为85-130 J/cm，脉冲宽度为10-40，脉冲数为1-4，每隔一个月进行一次。总治疗次数为1至2次。由两名医生通过测量标准照片中PG的长短径来计算PG体积的变化，从而进行临床疗效评估。根据治疗前和治疗后的照片，采用5分制评分量表评估色素清除情况：5分表示完全清除（95-100%），4分表示优秀（75-94%），3分表示良好（50-74%），2分表示中等（25-49%），1分表示差（0-24%）。在治疗后的随访中记录出血、瘢痕和色素沉着等不良反应。在这些患者中，28例单次治疗后痊愈，2例接受了两次治疗。首次激光治疗后，评分显著降低（p＜0.0001），同时医生的视觉评估有明显改善。所有患者在6个月的随访中均无复发。仅观察到1例患者有瘢痕。2例患者治疗后出现炎症后色素沉着，3个月内好转。治疗后未发现色素减退。1064纳米长脉冲Nd:YAG激光是治疗儿童PG的一种有效且安全的方法。
