Pham Peter, Lee Yvonne C
Chicago Medical School, Rosalind Franklin University, 3333 N Green Bay Rd, North Chicago, IL, 60064, USA.
Northwestern University Feinberg School of Medicine, 633 North St. Clair Street, 18-093, Chicago Illinois, 60611, USA.
Curr Rheumatol Rep. 2025 Mar 18;27(1):21. doi: 10.1007/s11926-025-01184-x.
Many individuals with rheumatoid arthritis (RA) continue to suffer from pain despite treatment with disease-modifying antirheumatic drugs. In this review, we aim to summarize the evidence for non-pharmacological approaches for managing pain in RA.
Few studies have examined the effect of non-pharmacological therapies on pain in patients with RA. Of these studies, many were not designed to specifically target pain and examined pain as a secondary outcome. While most studies reported within group improvements in pain, the magnitude of improvement varied, and differences between intervention and control groups often were not statistically significant. We recommend non-pharmacologic approaches for management of RA, based primarily on data for improving pain-related outcomes (e.g., physical function, overall health), as opposed to pain itself. The evidence base for non-pharmacologic interventions for pain remains poor, and there is a critical need for large RCTs designed to specifically target pain.
许多类风湿关节炎(RA)患者尽管接受了改善病情抗风湿药物治疗,但仍遭受疼痛困扰。在本综述中,我们旨在总结用于管理RA疼痛的非药物方法的证据。
很少有研究考察非药物疗法对RA患者疼痛的影响。在这些研究中,许多并非专门针对疼痛设计,而是将疼痛作为次要结果进行考察。虽然大多数研究报告了组内疼痛改善情况,但改善程度各不相同,干预组与对照组之间的差异往往无统计学意义。我们推荐用于RA管理的非药物方法,主要基于改善与疼痛相关结局(如身体功能、整体健康)的数据,而非疼痛本身。用于疼痛的非药物干预的证据基础仍然薄弱,迫切需要专门针对疼痛设计的大型随机对照试验。