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准备好的血管通路对日本老年和非老年慢性肾脏病G5期患者死亡率和医疗费用的影响:一项回顾性队列研究

Impact of prepared vascular access on mortality and medical expenses in elderly and non-elderly Japanese patients with chronic kidney disease stage G5: a retrospective cohort study.

作者信息

Nimura Takayuki, Harada Makoto, Aomura Daiki, Yamaka Kosuke, Hashimoto Koji, Kamijo Yuji

机构信息

Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.

出版信息

Clin Exp Nephrol. 2025 Mar 18. doi: 10.1007/s10157-025-02654-3.

DOI:10.1007/s10157-025-02654-3
PMID:40100518
Abstract

BACKGROUND

Patients with chronic kidney disease (CKD) stage 5 (CKDG5) have greater dialysis requirements that increase the risk of cardiovascular disease and mortality. The elevated costs associated with CKDG5 are a serious concern. The impact of prepared vascular access (VA) through planned VA creation on mortality and medical expenses remains unclear in Japanese patients with CKDG5.

METHODS

We conducted a retrospective cohort study including 157 patients with CKD who started hemodialysis (HD) at Shinshu University Hospital from April 2016 to March 2021 and assessed the relationship between the presence of a prepared VA and mortality and hospitalization expenses in elderly and non-elderly patients with CKDG5.

RESULTS

The presence of a prepared VA was associated with lower mortality in non-elderly patients but not in elderly patients. Medical expenses, emergency HD, and hospitalization duration were significantly lower in patients with a prepared VA in both age groups. The contribution of a prepared VA to mortality and medical expenses remained consistent after adjusting for sex, performance status, comorbidities, and nutritional status.

CONCLUSION

A prepared VA showed several benefits, including lower mortality rates and hospitalization costs; shorter hospital stays; and higher home discharge rates. Planned VA creation was significantly associated with lower hospitalization expenses, irrespective of age.

摘要

背景

慢性肾脏病(CKD)5期(CKDG5)患者的透析需求更高,这增加了心血管疾病风险和死亡率。与CKDG5相关的高昂费用是一个严重问题。在日本CKDG5患者中,通过计划性建立血管通路(VA)所准备好的血管通路对死亡率和医疗费用的影响仍不明确。

方法

我们进行了一项回顾性队列研究,纳入了2016年4月至2021年3月在信州大学医院开始血液透析(HD)的157例CKD患者,并评估了有准备好的血管通路与CKDG5老年和非老年患者的死亡率及住院费用之间的关系。

结果

有准备好的血管通路与非老年患者较低的死亡率相关,但与老年患者无关。两个年龄组中有准备好的血管通路的患者医疗费用、急诊HD次数和住院时间均显著更低。在调整性别、体能状态、合并症和营养状态后,准备好的血管通路对死亡率和医疗费用的影响仍然一致。

结论

准备好的血管通路显示出多种益处,包括较低的死亡率和住院费用;较短的住院时间;以及较高的出院回家率。计划性建立血管通路与较低的住院费用显著相关,与年龄无关。

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