Song Yan, Zhang Ying, Meng Haohao, Liu Jie, Gu Wenwen, Wang Xiru, Sang Zhongna
Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Hedong District Center for Disease Control and Prevention, Tianjin, 300171, China.
Biol Trace Elem Res. 2025 Mar 18. doi: 10.1007/s12011-025-04573-6.
There is a possibility that the iodine requirement for toddlers currently used in China is underestimated. This study aimed to conduct an iodine balance study in Chinese toddlers. We used a two-dose crossover experimental design, relying on the local iodine concentration in drinking water, and adjusting the iodine intake level by adjusting the toddlers' daily consumption of local drinking water. We measured daily iodine intake, excretion, and retention in toddlers and used linear mixed-effects models were used to fit the relationship between total iodine intake and iodine retention. This study involved 26 toddlers aged 2-3 years. Based on the daily total iodine intake and iodine balance values of the toddlers, a mixed effects model was applied to fit the regression curve, and the regression equation was obtained: y = 0.214x - 16.68, from which the EAR and RNI levels of the toddlers were calculated to be approximately 80 µg/day, and 110 µg/day, respectively. In our study, we expected the reference values for daily iodine EAR and RNI levels in toddlers with their current iodine nutrition status to be about 80 µg/day and 110 µg/day, respectively.
目前中国使用的幼儿碘需求量有可能被低估。本研究旨在对中国幼儿进行碘平衡研究。我们采用两剂量交叉实验设计，依据当地饮用水中的碘浓度，通过调整幼儿每日当地饮用水的摄入量来调节碘摄入量。我们测量了幼儿每日的碘摄入量、排泄量和潴留量，并使用线性混合效应模型来拟合总碘摄入量与碘潴留量之间的关系。本研究纳入了26名2至3岁的幼儿。根据幼儿的每日总碘摄入量和碘平衡值，应用混合效应模型拟合回归曲线，得到回归方程：y = 0.214x - 16.68，据此计算出幼儿的EAR和RNI水平分别约为80微克/天和110微克/天。在我们的研究中，我们预计处于当前碘营养状况的幼儿每日碘EAR和RNI水平的参考值分别约为80微克/天和110微克/天。
