Araki K, Kimura M, Sakamoto K, Nishimura R, Akagi M
Jpn J Surg. 1985 Mar;15(2):144-9. doi: 10.1007/BF02469745.
We carried out studies to determine whether the Tritiated Thymidine Labeling Index (TLI) would correlate with hormone receptors as well as with clinical and histological data. Sixty-four patients with breast cancer were the subjects studied. TLI showed no relationship to age, menopausal status, T-factor, n-factor, stage, or histological type. However, compared to tubule formation, nuclear pleomorphism, and mitotic activity, TLI showed a positive correlation with each and accordingly there was a positive correlation between TLI and Bloom's histological grading. The cumulative disease-free rate at three years was higher in case of a TLI below 4.0 (median TLI value). TLI significantly correlated inversely with the binding sites not only of cytoplasmic estrogen receptors (ERC), but also of cytoplasmic progesterone receptors (PRC) and nuclear estrogen receptors (ERN). Cancers negative for all three receptors indicated the highest TLI, while cancers positive for all three receptors showed the lowest TLI. The results suggest that breast cancers positive for hormone receptors were of low malignancy because lower TLI related to a lower proliferative activity. Thus, TLI is an useful parameter for assessing the clinical status of breast cancers.
我们开展了多项研究，以确定氚标记胸腺嘧啶核苷标记指数（TLI）是否与激素受体以及临床和组织学数据相关。64例乳腺癌患者为研究对象。TLI与年龄、绝经状态、T因子、n因子、分期或组织学类型均无关联。然而，与小管形成、核多形性和有丝分裂活性相比，TLI与之均呈正相关，因此TLI与布鲁姆组织学分级之间呈正相关。TLI低于4.0（TLI中位数）的患者三年累积无病生存率更高。TLI不仅与细胞质雌激素受体（ERC）的结合位点显著负相关，也与细胞质孕激素受体（PRC）和核雌激素受体（ERN）的结合位点显著负相关。三种受体均为阴性的癌症显示出最高的TLI，而三种受体均为阳性的癌症显示出最低的TLI。结果表明，激素受体阳性的乳腺癌恶性程度较低，因为较低的TLI与较低的增殖活性相关。因此，TLI是评估乳腺癌临床状态的一个有用参数。
