Kimura M
Nihon Geka Gakkai Zasshi. 1984 Aug;85(8):763-72.
Cytoplasmic estrogen receptor (ERC), nuclear estrogen receptor (ERN), and cytoplasmic progesterone receptor (PRC) were studied in 217 human breast cancers. ERC was found in 48.4%, ERN in 37.8%, and PRC in 32.7%. Histological grade was significantly correlated with ERC, ERN and PRC. Well-differentiated tumors were more frequently positive for the receptors while poorly differentiated tumors were generally negative for the receptors. Seventy one percent of the most differentiated tumors were ERC(+) ERN(+) PRC(+) and ERC(+) ERN(+) PRC(-). The histological grading system consists of tubule formation, nuclear pleomorphism and mitotic activity. There were significant correlations of receptor contents with nuclear pleomorphism and more mitotic activity. This was also confirmed by the study on the relationships between receptor contents and thymidine labeling index or mitotic index. The possibilities of receptors decreased with an increase in nuclear diameter. And there was a significant correlation between the receptor contents and the numbers of intracellular organellas in ultrastructural features of breast cancer cells. Among 33 cases of advanced or metastatic breast cancer submitted to endocrine therapy, 13 cases showed clinical response (CR or PR) These cases were both ERC and ERN positive independently of PRC status. Therefore, it is suggested that hormone receptor may be used as an independent prognostic factor in breast cancer.
对217例人类乳腺癌进行了细胞质雌激素受体（ERC）、细胞核雌激素受体（ERN）和细胞质孕激素受体（PRC）的研究。发现ERC阳性率为48.4%，ERN为37.8%，PRC为32.7%。组织学分级与ERC、ERN和PRC显著相关。高分化肿瘤受体阳性率较高，而低分化肿瘤受体通常为阴性。高分化肿瘤中71%为ERC(+) ERN(+) PRC(+)和ERC(+) ERN(+) PRC(-)。组织学分级系统包括小管形成、核多形性和有丝分裂活性。受体含量与核多形性和较高的有丝分裂活性显著相关。这也通过受体含量与胸腺嘧啶核苷标记指数或有丝分裂指数之间关系的研究得到证实。随着核直径增加，受体阳性的可能性降低。并且在乳腺癌细胞超微结构特征中，受体含量与细胞内细胞器数量之间存在显著相关性。在33例接受内分泌治疗的晚期或转移性乳腺癌病例中，13例显示临床反应（完全缓解或部分缓解）。这些病例无论PRC状态如何，均为ERC和ERN阳性。因此，提示激素受体可能作为乳腺癌独立的预后因素。
