Arnold Anne M, Singh Juhi, Sydlik Stefanie A
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
Department of Biomedical Engineering, Carnegie Mellon University, 346 Hamerschlag Drive, Pittsburgh, Pennsylvania 15213, United States.
Biomacromolecules. 2025 Apr 14;26(4):2015-2042. doi: 10.1021/acs.biomac.4c01431. Epub 2025 Mar 18.
Functional graphenic materials (FGMs) are materials derived from graphene oxide (GO) that hold a plethora of applications from electronics to nanomedicine. In this Perspective, we examine the history and evolution of biomedical applications of this carbon-based macromolecule. Following the carbon nanotube (CNT) movement, GO and FGMs became nanocarbons of interest because of their low cost and versatile functionality. The tunable chemistry enabled our work on FGMs coupled with biomacromolecules and allows FGMs to plays an important role in many biomedical applications, from tissue regeneration to controlled delivery. As we work to develop this material, it is critical to consider toxicity implications─in fresh materials as well as in degradation products. With this understanding, FGMs also hold potential roles in human health and environmental sustainability, making FGMs an important contemporary biomacromolecule.
功能化石墨烯材料（FGMs）是源自氧化石墨烯（GO）的材料，在从电子学到纳米医学等众多领域都有应用。在这篇观点文章中，我们审视了这种碳基大分子在生物医学应用方面的历史与发展。继碳纳米管（CNT）热潮之后，GO和FGMs因其低成本和多功能性而成为备受关注的纳米碳材料。可调控的化学性质使我们能够开展FGMs与生物大分子相结合的研究，并让FGMs在从组织再生到可控递送等诸多生物医学应用中发挥重要作用。在我们致力于开发这种材料时，考虑其毒性影响至关重要——无论是在新材料中还是在降解产物中。基于这种认识，FGMs在人类健康和环境可持续性方面也具有潜在作用，这使得FGMs成为一种重要的当代生物大分子。
