Xing Min, Qian Wenhao, Ye Kuicai, Zhang Haifeng, Feng Jiayin, Liu Xuanyong, Qiu Jiajun
Shanghai Xuhui District Dental Center, Shanghai, 200032, PR China.
Shanghai Xuhui District Dental Center, Shanghai, 200032, PR China.
Biomaterials. 2025 Sep;320:123251. doi: 10.1016/j.biomaterials.2025.123251. Epub 2025 Mar 14.
Enhancing the sealing between titanium abutment and surrounding soft tissue is crucial for preventing peri-implantitis. Meanwhile, exploring non-invasive antibacterial strategies as alternatives for traditional antibiotic therapy is central to improving the effect of peri-implantitis treatment. Furthermore, facilitating effective integration between titanium implant and osteoporotic bone is the cornerstone for ensuring long-term implant stability in patients with osteoporosis. In light of this, this work innovatively constructed multifunctional vertical graphene-based coatings on titanium implants and abutments using plasma-enhanced chemical vapor deposition technology. The results demonstrated that the vertical graphene coatings promoted soft tissue sealing and exhibited inherent antibacterial activities with the bacteriostasis rates of 65.60 % against Staphylococcus aureus (S. aureus) and 43.89 % against Escherichia coli (E. coli) in vitro which could prevent early infections. Moreover, vertical graphene coatings presented photothermal antibacterial effects with the antibacterial rates of 99.99 % and 95.83 % for S. aureus in vitro and in vivo, respectively, and 92.23 % for E. coli in vitro under near-infrared irradiation, which provided a non-invasive and highly effective treatment option for peri-implantitis. Furthermore, teriparatide acetate was loaded on vertical graphene coatings which enhanced osseointegration between titanium implants and osteoporotic bone. By comprehensively considering the critical functional requirements of dental implants and abutments, this work meticulously designed vertical graphene-based coatings on titanium dental implant systems for soft and hard tissue integration. This innovative design demonstrates immense application potential, especially for dental implant restoration in patients with osteoporosis.
增强钛基台与周围软组织之间的密封对于预防种植体周围炎至关重要。同时，探索非侵入性抗菌策略作为传统抗生素治疗的替代方法是提高种植体周围炎治疗效果的核心。此外，促进钛种植体与骨质疏松骨之间的有效整合是确保骨质疏松患者种植体长期稳定性的基石。鉴于此，本研究创新性地采用等离子体增强化学气相沉积技术在钛种植体和基台上构建了多功能垂直石墨烯基涂层。结果表明，垂直石墨烯涂层促进了软组织密封，并表现出固有的抗菌活性，在体外对金黄色葡萄球菌的抑菌率为65.60%，对大肠杆菌的抑菌率为43.89%，可预防早期感染。此外，垂直石墨烯涂层在近红外照射下对体外和体内金黄色葡萄球菌的抗菌率分别为99.99%和95.83%，对体外大肠杆菌的抗菌率为92.23%，呈现出光热抗菌效果，为种植体周围炎提供了一种非侵入性且高效的治疗选择。此外，将醋酸特立帕肽负载在垂直石墨烯涂层上，增强了钛种植体与骨质疏松骨之间的骨整合。通过综合考虑牙种植体和基台的关键功能要求，本研究精心设计了基于垂直石墨烯的钛牙种植体系统涂层，以实现软硬组织整合。这种创新设计显示出巨大的应用潜力，尤其适用于骨质疏松患者的牙种植体修复。
