Laurberg P
2. University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.
Endocrinology. 1977 Mar;100(3):656-62. doi: 10.1210/endo-100-3-656.
The effect of constant infusions of bovine TSH in different concentrations on the pattern of T4 and T3 secretion was examined in perfused canine thyroids isolated in situ. Each of the thyroid lobes was isolated and perfused in each animal. It was thus possible to examine the effect of two different concentrations of TSH in the same animal. The latency period was found to be shorter and the increase in hormone release was steeper when a high concentration of TSH (100 microU/ml) was infused than after a low concentration of TSH (2 microU/ml). The increase in T4 and T3 release started simultaneously; however, at all TSH concentrations employed a phase of relatively high secretion of T3 was induced. Despite continued infusion of TSH, the T4 T3 ratio in the effluent always returned to near prestimulation values at the end of the experiment. Accordingly, there was no support for a sustained enhancement of the preferential secretion of T3 from the thyroid during prolonged stimulation of the thyroid.
在原位分离的灌注犬甲状腺中，研究了不同浓度的牛促甲状腺激素持续输注对甲状腺素（T4）和三碘甲状腺原氨酸（T3）分泌模式的影响。在每只动物中，分离并灌注每个甲状腺叶。因此，有可能在同一只动物中研究两种不同浓度促甲状腺激素的作用。结果发现，当输注高浓度促甲状腺激素（100微单位/毫升）时，潜伏期较短，激素释放增加更为陡峭，而输注低浓度促甲状腺激素（2微单位/毫升）时则不然。T4和T3释放的增加同时开始；然而，在所使用的所有促甲状腺激素浓度下，均诱导了一个T3相对高分泌的阶段。尽管持续输注促甲状腺激素，但在实验结束时，流出液中的T4/T3比值总是恢复到接近刺激前的值。因此，没有证据支持在甲状腺长期刺激期间甲状腺优先分泌T3的持续增强。
