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From lipotoxicity to pan-lipotoxicity.

作者信息

Cheng Yiping, Shao Shanshan, Wang Zhen, Guan Qingbo, Li Huaxue, Liu Guodong, Zhang Haiqing, Fan Xiude, Zhao Jiajun

机构信息

Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Shandong Key Laboratory of Endocrine Metabolism and Aging, Jinan, Shandong, China.

出版信息

Cell Discov. 2025 Mar 18;11(1):27. doi: 10.1038/s41421-025-00787-z.

DOI:10.1038/s41421-025-00787-z
PMID:40102396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11920229/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/11920229/26cf77e16787/41421_2025_787_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/11920229/26cf77e16787/41421_2025_787_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/11920229/26cf77e16787/41421_2025_787_Fig1_HTML.jpg

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本文引用的文献

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Oxidized phospholipids in cardiovascular disease.氧化磷脂在心血管疾病中的作用。
Nat Rev Cardiol. 2024 Mar;21(3):170-191. doi: 10.1038/s41569-023-00937-4. Epub 2023 Oct 17.
2
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.用佩马弗他酯降低甘油三酯以降低心血管风险。
N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5.
3
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases.胆固醇诱导的毒性：胆固醇在多种疾病中的作用的综合观点。
Cell Metab. 2021 Oct 5;33(10):1911-1925. doi: 10.1016/j.cmet.2021.09.001. Epub 2021 Sep 24.
4
Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis.全球非肥胖或消瘦非酒精性脂肪性肝病的患病率、发病率和结局：系统评价和荟萃分析。
Lancet Gastroenterol Hepatol. 2020 Aug;5(8):739-752. doi: 10.1016/S2468-1253(20)30077-7. Epub 2020 May 12.
5
Triglyceride-Rich Lipoprotein Cholesterol, Small Dense LDL Cholesterol, and Incident Cardiovascular Disease.富含甘油三酯的脂蛋白胆固醇、小而密 LDL 胆固醇与心血管疾病事件。
J Am Coll Cardiol. 2020 May 5;75(17):2122-2135. doi: 10.1016/j.jacc.2020.02.059.
6
The endocrine function of adipose tissues in health and cardiometabolic disease.健康与心血管代谢疾病中的脂肪组织内分泌功能。
Nat Rev Endocrinol. 2019 Sep;15(9):507-524. doi: 10.1038/s41574-019-0230-6. Epub 2019 Jul 11.
7
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.鞘脂从头合成：心血管稳态的调节器
Trends Endocrinol Metab. 2016 Nov;27(11):807-819. doi: 10.1016/j.tem.2016.07.005. Epub 2016 Aug 22.
8
Ceramides - Lipotoxic Inducers of Metabolic Disorders.神经酰胺——代谢紊乱的脂毒性诱导剂。
Trends Endocrinol Metab. 2015 Oct;26(10):538-550. doi: 10.1016/j.tem.2015.07.006.
9
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.载脂蛋白 C3 基因变异与非酒精性脂肪性肝病。
N Engl J Med. 2010 Mar 25;362(12):1082-9. doi: 10.1056/NEJMoa0907295.
10
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.肥胖大鼠非胰岛素依赖型糖尿病发病机制中的β细胞脂毒性：脂肪细胞与β细胞关系受损。
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10878-82. doi: 10.1073/pnas.91.23.10878.