Department of Clinical Laboratory, First People's Hospital of Linping District, Hangzhou, Zhejiang, China.
Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Front Public Health. 2024 May 30;12:1357311. doi: 10.3389/fpubh.2024.1357311. eCollection 2024.
Limited data exist on HPV prevalence and genotyping during the COVID-19 pandemic. A total of 130,243 samples from 129, 652 women and 591 men who visited the First People's Hospital of Linping District between 2016 and 2022 were recruited. HPV genotypes were detected by polymerase chain reaction (PCR) amplification and nucleic acid molecular hybridization. Then the prevalence characteristics of HPV genotypes and trends in HPV infection rates from 2016 to 2022 were analyzed. Results showed that among the study population, the overall prevalence of HPV infection was 15.29%, with 11.25% having single HPV infections and 4.04% having multiple HPV infections, consistent with previous findings. HPV genotypes exhibited similar distribution patterns in both male and female groups, with HPV16, HPV52, HPV58, HPV18, and HPV39 being the most prevalent. Age-related analysis unveiled a bimodal pattern in HPV prevalence, with peaks in infection rates observed in individuals below 20 and those aged 61-65 years. Comparing the pre- and during COVID-19 periods revealed significant disparities in HPV infections, with variations in specific HPV genotypes, including 16, 18, 35, 45, 52, 58, 59, and 68. This study provides valuable insights into the prevalence, distribution, and epidemiological characteristics of HPV infections in a large population. It also highlights the potential impact of the COVID-19 pandemic on HPV trends.
关于 COVID-19 大流行期间 HPV 的流行率和基因型的数据有限。共招募了 129652 名女性和 591 名男性，他们于 2016 年至 2022 年期间参观了临平区第一人民医院的 130243 个样本。HPV 基因型通过聚合酶链反应（PCR）扩增和核酸分子杂交检测。然后分析了 HPV 基因型的流行特征以及 2016 年至 2022 年 HPV 感染率的趋势。结果表明，在研究人群中，HPV 感染的总体流行率为 15.29%，其中 11.25%为单一 HPV 感染，4.04%为多重 HPV 感染，与以往的研究结果一致。HPV 基因型在男性和女性群体中的分布模式相似，HPV16、HPV52、HPV58、HPV18 和 HPV39 最为常见。年龄相关分析显示 HPV 流行率呈双峰模式，20 岁以下和 61-65 岁人群的感染率最高。比较 COVID-19 前后期间的 HPV 感染情况，发现特定 HPV 基因型存在显著差异，包括 16、18、35、45、52、58、59 和 68。本研究提供了关于大人群中 HPV 感染的流行率、分布和流行病学特征的有价值的见解。它还强调了 COVID-19 大流行对 HPV 趋势的潜在影响。
