Pritchard T J, Madara J L, Tapper D, Wilmore D W, Kirkman R L
J Surg Res. 1985 Jun;38(6):553-8. doi: 10.1016/0022-4804(85)90075-7.
The effect of cyclosporine (CyS) on survival and function of 250 cm intraabdominal heterotopic small bowel allografts was studied in outbred pigs. Experimental animals received oral CyS alone (25 mg/kg/day), or oral CyS, donor bowel radiation, and recipient splenectomy; controls were untreated. Excluding technical failures, no significant differences in graft survival were observed, although one relatively long-term survivor occurred in each treated group. Rejection was not related to cyclosporine levels. These data show that CyS as a single agent as well as when used with supplemental therapy does not uniformly prevent rejection of small bowel allografts in pigs, although an occasional long-term survivor will occur. The failure to achieve consistently successful engraftment may reflect the large quantity of lymphoid tissue in small bowel. Further experimentation is required before human transplantation is again attempted.
在远交群猪中研究了环孢素（CyS）对250厘米腹腔内异位小肠同种异体移植存活及功能的影响。实验动物单独接受口服CyS（25毫克/千克/天），或口服CyS、供体肠辐射及受体脾切除术；对照组未接受治疗。排除技术失败情况，尽管每个治疗组都出现了1例相对长期存活者，但在移植存活方面未观察到显著差异。排斥反应与环孢素水平无关。这些数据表明，CyS单独使用以及与补充疗法联合使用时，均不能一致地预防猪小肠同种异体移植的排斥反应，尽管偶尔会出现长期存活者。未能始终成功实现植入可能反映了小肠中大量的淋巴组织。在再次尝试进行人体移植之前，需要进一步的实验。
