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荟萃分析：准分子原位角膜磨镶术（LASIK）和准分子激光角膜切削术（PRK）治疗远视的临床结果

Meta-analysis: clinical outcomes of laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in hyperopia.

作者信息

Almutairi Mohammed Naji, Alshehri Abdullrahman M, Alhoumaily Abdulrahman Y, Alnahdi Osamah, Taha Mohammed A, Gangadharan Shiji

机构信息

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

BMC Ophthalmol. 2025 Mar 18;25(1):140. doi: 10.1186/s12886-025-03956-6.

DOI:10.1186/s12886-025-03956-6
PMID:40102791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917003/
Abstract

BACKGROUND

To evaluate differences in clinical outcome, safety, and efficacy of photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK) in the correction of hyperopic refractive errors.

METHODS

We have adhered to PRISMA criteria in this systematic review, which is registered with PROSPERO (CRD42023469543). Our search with studies comparing PRK and LASIK for hyperopia was conducted through the databases PubMed, EMBASE, Web of Science, and the Cochrane Library. We used the Cochrane method to assess bias and evaluated variables like uncorrected distance visual acuity and mean spherical equivalent. Using fixed- or random-effects models, a meta-analysis was performed using RevMan 5.4 for evaluating heterogeneity and significance. Sensitivity analysis addressed the causes of heterogeneity to assure stability.

RESULTS

We included 6 articles (419 participants, 585 eyes) in this review five were retrospective and 1 case-series. The final mean refractive SE (WMD, -0.05; 95% confidence interval [CI], 0.42 to 0.31; P = 0.06). patients achieving uncorrected distance visual acuity (UDVA) of 20/20 or better (OR, 0.58; 95% CI, 0.39-0.78; P = 0.33). final UDVA of 20/40 or better (OR, 1.40; 95% CI, 0.65-3.02; P = 0.81) were analyzed.

CONCLUSIONS

In this meta-analysis, LASIK had no significant benefits over PRK in relation to clinical outcomes. Less corneal haze was observed in LASIK-treated eyes at 1 to 3 months after surgery.

摘要

背景

评估准分子激光角膜切削术（PRK）和准分子原位角膜磨镶术（LASIK）在矫正远视性屈光不正方面的临床结局、安全性和有效性差异。

方法

在本系统评价中，我们遵循了PRISMA标准，该评价已在PROSPERO（CRD42023469543）注册。我们通过PubMed、EMBASE、科学网和Cochrane图书馆数据库检索比较PRK和LASIK治疗远视的研究。我们使用Cochrane方法评估偏倚，并评估如未矫正远视力和平均球镜等效度等变量。使用固定效应或随机效应模型，使用RevMan 5.4进行荟萃分析以评估异质性和显著性。敏感性分析探讨了异质性的原因以确保稳定性。

结果

本评价纳入6篇文章（419名参与者，585只眼），其中5篇为回顾性研究，1篇为病例系列研究。最终平均屈光球镜等效度（加权均数差，-0.05；95%置信区间[CI]，-0.42至0.31；P = 0.06）。分析了未矫正远视力（UDVA）达到20/20或更好的患者（比值比，0.58；95%CI，0.39 - 0.78；P = 0.33）。最终UDVA达到20/40或更好的患者（比值比，1.40；95%CI，0.65 - 3.02；P = 0.81）。

结论

在本荟萃分析中，LASIK在临床结局方面相对于PRK没有显著优势。术后1至3个月，LASIK治疗的眼睛角膜 haze较少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbef/11917003/7cb425d7d907/12886_2025_3956_Fig14_HTML.jpg
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Long-term results of hyperopic ablations using alcohol-assisted PRK and FS-LASIK: comparative study.远视性消融术使用酒精辅助 PRK 和 FS-LASIK 的长期效果：对比研究。
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