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用于再生医学的间充质干细胞功能化细胞外囊泡

Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine.

作者信息

Yoo Donghyeon, Jung Se Young, Go Dabin, Park Ji Yeong, You Dong Gil, Jung Won-Kyo, Li Yuce, Ding Jianxun, Park Jae Hyung, Um Wooram

机构信息

Department of Biotechnology, College of Fisheries Science, Pukyong National University, Busan, 48513, Republic of Korea.

Department of Chemical Engineering & Biotechnology, Tech University of Korea, Siheung, 15073, Republic of Korea.

出版信息

J Nanobiotechnology. 2025 Mar 18;23(1):219. doi: 10.1186/s12951-025-03300-6.

DOI:10.1186/s12951-025-03300-6
PMID:40102934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11921732/
Abstract

Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by certain stem cell preconditioning methods, providing an exceptional opportunity to enhance the therapeutic potential or confer additional functions of stem cell-derived EVs. In this review, we discuss the recent progress of functionalized EVs, based on stem cell preconditioning, for treating various organ systems, such as the musculoskeletal system, nervous system, integumentary system, cardiovascular system, renal system, and respiratory system. Additionally, we summarize the expected outcomes of preconditioning methods for stem cells and their EVs. With recent progress, we suggest considerations and future directions for developing personalized medicine based on preconditioned stem cell-derived EVs.

摘要

近几十年来，干细胞衍生的细胞外囊泡（EVs）已成为再生医学中一种安全且有效的替代方案。此外，最近通过某些干细胞预处理方法能够对EV的功能进行调节，这为增强干细胞衍生EV的治疗潜力或赋予其额外功能提供了绝佳机会。在这篇综述中，我们讨论了基于干细胞预处理的功能化EV在治疗各种器官系统（如肌肉骨骼系统、神经系统、皮肤系统、心血管系统、肾脏系统和呼吸系统）方面的最新进展。此外，我们总结了干细胞及其EV预处理方法的预期结果。随着最近的进展，我们提出了基于预处理的干细胞衍生EV开发个性化药物的注意事项和未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/2fd9cc35593c/12951_2025_3300_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/f7878ee8494f/12951_2025_3300_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/b67c2a0694fb/12951_2025_3300_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/2fd9cc35593c/12951_2025_3300_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/f7878ee8494f/12951_2025_3300_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/b67c2a0694fb/12951_2025_3300_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d86/11921732/2fd9cc35593c/12951_2025_3300_Fig3_HTML.jpg

相似文献

[1]
Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine.

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[2]
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[8]
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[9]
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引用本文的文献

[1]
Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy.

J Nanobiotechnology. 2025-8-20

[2]
Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration.

J Nanobiotechnology. 2025-7-26

[3]
Conditioned medium from adipose mesenchymal stromal cells stimulated with pituitary adenylate cyclase-activating polypeptide (PACAP) mitigates RINm5F pancreatic β-cell dysfunction.

Mol Biol Rep. 2025-7-9

[4]
The Role of Extracellular Vesicles in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Liver Diseases.

Int J Mol Sci. 2025-5-23

本文引用的文献

[1]
Chondroitin sulfate-based microneedles for transdermal delivery of stem cell-derived extracellular vesicles to treat rheumatoid arthritis.

J Control Release. 2024-11

[2]
Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity.

Nat Nanotechnol. 2024-4

[3]
Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment.

Int J Med Sci. 2024

[4]
Hypoxic bone marrow mesenchymal stem cell-derived exosomal lncRNA XIST attenuates lipopolysaccharide-induced acute lung injury via the miR-455-3p/Claudin-4 axis.

Int Immunopharmacol. 2023-12

[5]
Adipose Mesenchymal Stem Cell Derived Exosomes Promote Keratinocytes and Fibroblasts Embedded in Collagen/Platelet-Rich Plasma Scaffold and Accelerate Wound Healing.

Adv Mater. 2023-10

[6]
Emerging frontiers in regenerative medicine.

Science. 2023-5-26

[7]
miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury.

Redox Biol. 2023-6

[8]
The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases.

Cell Commun Signal. 2023-1-23

[9]
Extracellular vesicles in the pathogenesis and treatment of acute lung injury.

Mil Med Res. 2022-11-1

[10]
Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis.

Bioact Mater. 2022-10-19

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