Schafer L W, Larson D E, Melton L J, Higgins J A, Zinsmeister A R
Mayo Clin Proc. 1985 Jul;60(7):444-8. doi: 10.1016/s0025-6196(12)60867-2.
To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.
为了确定恶性贫血患者患胃癌的长期风险，我们找出了明尼苏达州罗切斯特市的152名居民，他们在1950年至1979年的30年间有记录完善的恶性贫血病史。这些患者随后接受了超过1550人年的随访观察。将该队列中观察到的胃癌发生风险与根据当地人群胃癌发病率预期的风险进行比较。我们在152例恶性贫血患者中发现了1例胃癌病例，而预期发病率为1.02（相对风险为1.0；95%置信区间为0.02至5.5）。我们得出结论，对于无症状的恶性贫血患者，无论是影像学检查还是内镜检查监测，都没有强有力的指征。
