Li Yongtian, Gu Bianli, Ma Lixia, He Li-Na, Bao Xiaoqiong, Huang Yuantai, Yang Rui, Wang Li, Yang Qingtao, Yang Haibo, Zuo Zhixiang, Gao Shegan, Zhao Xueya, Chen Ke
Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China.
Comput Struct Biotechnol J. 2025 Feb 21;27:813-820. doi: 10.1016/j.csbj.2025.02.018. eCollection 2025.
Circular RNA (circRNA) is a class of noncoding RNAs derived from back-splicing of pre-mRNAs. Recent studies have increasingly highlighted the pivotal roles of N6-methyladenosine (m6A) in regulating various aspects of circRNA metabolism, including biogenesis, localization, stability, and translation. Despite the importance of m6A in circRNA metabolism, there remains a substantial gap in comprehensive resources dedicated to exploring m6A modification in circRNA. To bridge this significant gap, we present m6A2Circ (http://m6a2circ.canceromics.org/), a pioneering database designed to systematically explore the regulatory interactions between m6A modification and circRNA. The m6A2Circ database encompasses 198,804 m6A-circRNA associations derived from diverse human and mouse tissues. These associations are meticulously categorized into four levels of evidence supported either by experimental data or by high-throughput sequencing data. Moreover, the database offers extensive annotations, facilitating research into circRNA function and its potential disease implications. Overall, m6A2Circ aims to benefit the research community and bolster novel discoveries in terms of crosstalk between m6A and circRNA.
环状RNA（circRNA）是一类由前体信使核糖核酸（pre-mRNA）反向剪接产生的非编码RNA。最近的研究越来越多地强调了N6-甲基腺苷（m6A）在调节circRNA代谢的各个方面所起的关键作用，包括生物发生、定位、稳定性和翻译。尽管m6A在circRNA代谢中很重要，但在专门探索circRNA中m6A修饰的综合资源方面仍存在很大差距。为了弥补这一重大差距，我们推出了m6A2Circ（http://m6a2circ.canceromics.org/），这是一个开创性的数据库，旨在系统地探索m6A修饰与circRNA之间的调控相互作用。m6A2Circ数据库包含来自不同人类和小鼠组织的198,804个m6A-circRNA关联。这些关联被细致地分为由实验数据或高通量测序数据支持的四个证据级别。此外，该数据库提供了广泛的注释，便于对circRNA功能及其潜在的疾病影响进行研究。总体而言，m6A2Circ旨在造福研究界，并促进在m6A与circRNA之间的相互作用方面取得新的发现。
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