Perrotta Giulio
Psychology and Psychotherapy Istituto per lo Studio delle Psicoterapie (I.S.P.) Rome Lazio Italy.
Ibrain. 2024 Dec 20;11(1):19-31. doi: 10.1002/ibra.12190. eCollection 2025 Spring.
Borderline personality disorder (BPD) is a dysfunctional, stable, and pervasive alteration in personality functioning with the inability to adapt to the environment, mental rigidity, and ego-syntonic. High suicidality in BPD patients underlines the significance of research into its pathology. While extensive research on the psychological and behavioral manifestations of BPD can be found in literature, the neuropsychological aspects of the disorder are still partially unknown, although the roles of certain brain structures in the manifestation of the pathology, such as the amygdala, hippocampus, insula, medial prefrontal and cingulate cortices, nucleus accumbens, and temporo-occipital areas, have already been clarified. This review aims to synthesize current knowledge of the neuroanatomical and functional correlates of BPD, providing insights that may inform future research and therapeutic strategies.
边缘型人格障碍（BPD）是一种人格功能失调、稳定且普遍存在的改变，表现为无法适应环境、心理僵化且与自我观念一致。BPD患者的高自杀率凸显了对其病理学进行研究的重要性。虽然在文献中可以找到关于BPD心理和行为表现的大量研究，但该障碍的神经心理学方面仍部分未知，尽管某些脑结构在病理学表现中的作用，如杏仁核、海马体、脑岛、内侧前额叶和扣带回皮质、伏隔核以及颞枕叶区域，已经得到阐明。本综述旨在综合当前关于BPD神经解剖学和功能相关性的知识，提供可能为未来研究和治疗策略提供参考的见解。
