He Yi, Li Lian, Zhou Ting, Yang Hao, Liu Tao, Hu Houyuan
Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
J Inflamm Res. 2025 Mar 13;18:3807-3816. doi: 10.2147/JIR.S501429. eCollection 2025.
Inflammation plays an important role in the pathogenesis of coronary artery calcification (CAC). This study aims to explore the potential association between inflammation indices derived from complete blood count (CBC) and CAC, including the neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), neutrophil-monocyte to lymphocyte ratio (NMLR), systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), aggregate index of systemic inflammation (AISI), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR).
We systematically collected data from patients who underwent CAC scoring via cardiac CT at our hospital between July 2018 and June 2023. Patients were divided into two groups based on the presence or absence of CAC. Multivariate logistic regression analysis, smooth curve fitting, and threshold effect analysis were subsequently used to explore the potential linear or nonlinear relationships between CBC-derived inflammation indices and CAC. Subgroup analyses were conducted to examine the consistency of these findings across different subgroups.
A total of 2143 participants were included in this study: the CAC group (1286 participants) and the non-CAC group (857 participants). In the four subgroups of CAC, within-group comparisons revealed that alkaline phosphatase (ALP), smoking status, and peripheral artery plaques were more prevalent in the group with CAC scores > 400. After adjusting for confounding variables, we found that the total NLR, NMLR, SIRI, and AISI were positively associated with CAC. Subsequently, we identified a nonlinear relationship between MLR and CAC, with a threshold value of 0.236. Additionally, subgroup analysis indicated that these associations remained stable across various subgroups.
This study indicates that the total NLR, NMLR, SIRI, and AISI are significantly positively correlated with CAC in a linear association, while MLR exhibits a nonlinear relationship with CAC. In contrast, SII, PLR, and dNLR show no significant association with CAC.
炎症在冠状动脉钙化（CAC）的发病机制中起重要作用。本研究旨在探讨全血细胞计数（CBC）得出的炎症指标与CAC之间的潜在关联，包括中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、中性粒细胞 - 单核细胞与淋巴细胞比值（NMLR）、全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）、全身炎症聚集指数（AISI）、血小板与淋巴细胞比值（PLR）以及单核细胞与淋巴细胞比值（MLR）。
我们系统收集了2018年7月至2023年6月期间在我院接受心脏CT进行CAC评分的患者的数据。根据是否存在CAC将患者分为两组。随后采用多因素逻辑回归分析、平滑曲线拟合和阈值效应分析来探讨CBC得出的炎症指标与CAC之间潜在的线性或非线性关系。进行亚组分析以检验这些发现在不同亚组中的一致性。
本研究共纳入2143名参与者：CAC组（1286名参与者）和非CAC组（857名参与者）。在CAC的四个亚组中，组内比较显示，碱性磷酸酶（ALP）、吸烟状况和外周动脉斑块在CAC评分>400的组中更为普遍。在调整混杂变量后，我们发现总NLR、NMLR、SIRI和AISI与CAC呈正相关。随后，我们确定MLR与CAC之间存在非线性关系，阈值为0.236。此外，亚组分析表明这些关联在各个亚组中保持稳定。
本研究表明，总NLR、NMLR、SIRI和AISI与CAC呈显著正相关且为线性关联，而MLR与CAC呈非线性关系。相比之下，SII、PLR和dNLR与CAC无显著关联。
