Department of Cardiology, Fırat University Faculyt of Medicine, Elazıg, Turkey.
Department of Cardiology, Fethi Sekin Sehir Hastanesi, Elazıg, Turkey.
BMC Cardiovasc Disord. 2023 Mar 23;23(1):146. doi: 10.1186/s12872-023-03157-3.
İNTRODUCTION: Patients with normal coronary arteries in whom increased vasospasm cannot be detected with the stress test should be evaluated in terms of cardiac syndrome x (CSX). İnflammatory systems are effective in endothelial activation and dysfunction in CSX. The systemic immune inflammation index (SII) is thought to be an important factor in determining the course of diseases, especially in infectious diseases or other diseases, as an indicator of the inflammation process. The aim of this study is to determine the role of SII levels in the diagnosis of CSX disease.
The study group included 80 patients who applied to the cardiology department of Fırat University with typical anginal complaints between October 2021 and April 2022, and were diagnosed with ischemia after the myocardial perfusion scan, and then coronary angiography was performed and normal coronary arteries were observed.
When the study and control groups were examined according to age, gender and body mass index, hypertension, smoking, diabetes mellitus, dyslipidemia and family history, no statistical significant difference was observed between the groups. It was observed that there was a significant difference between the high sensitive C- reactive protin levels of the individuals in the study and control groups (p = 0.028). SII levels measured in samples taken from patients were significantly higher than control subjects (p = 0.003). SII cutoff at admission was 582 with 82% sensitivity and 84% specificity (area under the curve 0.972; 95% CI:0.95-0.98;p < 0.001).
It has been demonstrated that systemic SII parameters, which can be simply calculated with the data obtained from the complete blood count and do not require additional costs, can contribute to the prediction of CSX disease.
介绍在应激试验中无法检测到正常冠状动脉患者的血管痉挛增加的情况下，应从心脏综合征 X（CSX）方面进行评估。炎症系统在 CSX 的内皮激活和功能障碍中起作用。全身免疫炎症指数（SII）被认为是确定疾病进程的重要因素，特别是在传染病或其他疾病中，作为炎症过程的指标。本研究旨在确定 SII 水平在 CSX 疾病诊断中的作用。
研究组纳入了 2021 年 10 月至 2022 年 4 月间因典型心绞痛症状就诊于费拉特大学心脏病科的 80 例患者，这些患者在心肌灌注扫描后被诊断为缺血，随后进行了冠状动脉造影，观察到正常的冠状动脉。
按年龄、性别和体重指数、高血压、吸烟、糖尿病、血脂异常和家族史对研究组和对照组进行检查时，两组之间无统计学显著差异。研究组和对照组个体的高敏 C 反应蛋白水平存在显著差异（p=0.028）。从患者样本中测量的 SII 水平明显高于对照组（p=0.003）。入院时 SII 截断值为 582，灵敏度为 82%，特异性为 84%（曲线下面积 0.972；95%CI：0.95-0.98；p<0.001）。
研究表明，全身 SII 参数可以通过血常规获得的数据简单计算，且无需额外费用，有助于预测 CSX 疾病。
