Javed Shireen, Mohamed Mahaneem, Altaf Benash, Ghazali Wan Syaheedah Wan
Shireen Javed, (MBBS, MPhil, PhD Scholar) Associate Professor, Department of Physiology Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan.
Mahaneem Mohamed, (MD, PhD) Associate Professor, Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Pak J Med Sci. 2025 Mar;41(3):712-718. doi: 10.12669/pjms.41.3.10841.
To evaluate the impact of Type 2 diabetes mellitus (T2DM) on quality of life (QOL) and compare it with healthy subjects.
This case-control study was conducted at Aziz Fatimah Hospital and Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan, from May 2023 to January 2024. A total of 170 subjects were included in the study through purposive sampling technique. Fasting and random blood glucose levels were measured using an enzymatic colorimetric test. HbA1c was determined with the Bioherms A1C EZ 2.0 Glyco-hemoglobin Test Kit. QOL was assessed using the Short Form-36 version 1 questionnaire. Statistical analysis was performed using SPSS version 26, with p ≤ 0.05 considered significant.
The study included 86 T2DM patients and 84 controls, with a mean age of 49.23 ± 12.59 years. Among the participants, 44.7% were male and 55.3% were female. T2DM patients scored lower in physical functioning, limitations due to physical health, bodily pain and vitality subscale compared to controls (p = 0.003, 0.050, 0.030, 0.000 respectively). Both groups had physical component summary and mental component summary (MCS) scores below 50, indicating impaired QOL. MCS scores were significantly lower in T2DM patients than in controls (p = 0.002). Females scored lower in vitality (p = 0.0005) and bodily pain (p = 0.031). T2DM patients with less than five years of duration had lower SF-36 scores than those with longer duration.
T2DM impairs quality of life, especially in females and those with less than five years of disease duration, who face a greater negative impact.
评估2型糖尿病（T2DM）对生活质量（QOL）的影响，并将其与健康受试者进行比较。
本病例对照研究于2023年5月至2024年1月在巴基斯坦费萨拉巴德的阿齐兹·法蒂玛医院和阿齐兹·法蒂玛医学与牙科学院进行。通过目的抽样技术，共纳入170名受试者。采用酶比色法测量空腹和随机血糖水平。使用Bioherms A1C EZ 2.0糖化血红蛋白检测试剂盒测定糖化血红蛋白（HbA1c）。使用简明健康状况调查问卷第1版评估生活质量。采用SPSS 26版进行统计分析，p≤0.05被认为具有统计学意义。
该研究纳入了86例T2DM患者和84例对照，平均年龄为49.23±12.59岁。参与者中，44.7%为男性，55.3%为女性。与对照组相比，T2DM患者在生理功能、身体健康所致的限制、身体疼痛和活力子量表上得分较低（分别为p = 0.003、0.050、0.030、0.000）。两组的生理健康综合评分和心理健康综合评分（MCS）均低于50分，表明生活质量受损。T2DM患者的MCS评分显著低于对照组（p = 0.002）。女性在活力（p = 0.0005）和身体疼痛（p = 0.031）方面得分较低。病程少于5年的T2DM患者的SF-36评分低于病程较长的患者。
T2DM会损害生活质量，尤其是女性和病程少于5年的患者，他们面临更大的负面影响。
