Lalhmangaihzuala Samson, Khiangte Vanlalngaihawma, Vanlaldinpuia Khiangte
Department of Chemistry, Pachhunga University College, Mizoram University Aizawl 796001 Mizoram India
Department of Chemistry, Mizoram University Tanhril Aizawl 796004 Mizoram India.
RSC Adv. 2025 Mar 18;15(11):8335-8345. doi: 10.1039/d5ra00456j. eCollection 2025 Mar 17.
In this study, a series of sixteen (16) d-fructose-based bifunctional thioureas were examined as organocatalysts for the enantioselective Friedel-Crafts alkylation of indoles and pyrrole with β-nitrostyrenes. This investigation is a part of our ongoing project, which aims to expand the scope of application of d-fructose-based thioureas. Under the optimized low-temperature reaction conditions, the corresponding adducts were obtained with good yield (up to 95%) and excellent enantioselectivity (>99% ee).
在本研究中，考察了一系列十六种（16种）基于d-果糖的双功能硫脲作为吲哚和吡咯与β-硝基苯乙烯对映选择性傅克烷基化反应的有机催化剂。本研究是我们正在进行的项目的一部分，该项目旨在扩大基于d-果糖的硫脲的应用范围。在优化的低温反应条件下，以良好的产率（高达95%）和优异的对映选择性（>99% ee）得到了相应的加合物。
