• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

科里-富克斯反应助力天然产物的合成：综述

Corey-Fuchs reaction enabled synthesis of natural products: a review.

作者信息

Ashraf Rabia, Zahoor Ameer Fawad, Khan Samreen Gul, Saif Muhammad Jawwad, Hussain Syed Makhdoom, Raza Naqvi Syed Ali, Parveen Bushra, Ali Kulsoom Ghulam, Mansha Asim, Irfan Ahmad

机构信息

Department of Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan

Department of Applied Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan.

出版信息

RSC Adv. 2025 Mar 17;15(11):8121-8155. doi: 10.1039/d5ra00619h.

DOI:10.1039/d5ra00619h
PMID:40103970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11912353/
Abstract

Natural products can be derived from a vast array of animals, plants and microorganisms and are generally characterized by a wide spectrum of bioactive properties such as anti-viral, anti-cancer, anti-inflammatory and anti-bacterial properties. Synthesis of natural products is of paramount importance in various fields including medicine, biotechnology and agriculture. The Corey-Fuchs reaction, also known as the Ramirez Corey-Fuchs reaction, is a pivotal organic transformation and plays a significant role in the synthesis of intricate natural products and their analogues. This review article highlights the development of the Corey-Fuchs reaction in recent years towards the synthesis of complex natural products including polyketides, alkaloids, terpenoids and peptides.

摘要

天然产物可以从大量的动物、植物和微生物中提取，其一般具有广泛的生物活性特性，如抗病毒、抗癌、抗炎和抗菌特性。天然产物的合成在医学、生物技术和农业等各个领域都至关重要。科里-富克斯反应，也称为拉米雷斯-科里-富克斯反应，是一种关键的有机转化反应，在复杂天然产物及其类似物的合成中发挥着重要作用。这篇综述文章重点介绍了近年来科里-富克斯反应在合成包括聚酮化合物、生物碱、萜类化合物和肽类在内的复杂天然产物方面的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/3195a0862cde/d5ra00619h-s32.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/d7d554c9868d/d5ra00619h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/366610e66d09/d5ra00619h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/8496c1b15f64/d5ra00619h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c902b63a8234/d5ra00619h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/81e5d7784f67/d5ra00619h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/9c1b8abdc4ce/d5ra00619h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/24b88857238f/d5ra00619h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/06525a652bb1/d5ra00619h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/5b12455ace23/d5ra00619h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/1e231d453b14/d5ra00619h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/70aacba65f18/d5ra00619h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4432373937f2/d5ra00619h-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/f7c6191f9740/d5ra00619h-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/d4293cb3bfd2/d5ra00619h-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/92bef7d01521/d5ra00619h-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/aef18522aa78/d5ra00619h-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/07642a101340/d5ra00619h-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/cc7bde75cc45/d5ra00619h-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/131964f4b94b/d5ra00619h-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4580a759cc5f/d5ra00619h-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c4c3724feeae/d5ra00619h-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/790935c5822a/d5ra00619h-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/55b4a3568474/d5ra00619h-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/bcd4081ff089/d5ra00619h-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4f49770f52b7/d5ra00619h-s24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4ee2d7f2e289/d5ra00619h-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/b37eabc9efe2/d5ra00619h-s26.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/80d18ef1410d/d5ra00619h-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c2a370973253/d5ra00619h-s28.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/663404ca6676/d5ra00619h-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/34826a801001/d5ra00619h-s30.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/0d20f8f7e52d/d5ra00619h-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/3195a0862cde/d5ra00619h-s32.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/d7d554c9868d/d5ra00619h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/366610e66d09/d5ra00619h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/8496c1b15f64/d5ra00619h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c902b63a8234/d5ra00619h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/81e5d7784f67/d5ra00619h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/9c1b8abdc4ce/d5ra00619h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/24b88857238f/d5ra00619h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/06525a652bb1/d5ra00619h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/5b12455ace23/d5ra00619h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/1e231d453b14/d5ra00619h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/70aacba65f18/d5ra00619h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4432373937f2/d5ra00619h-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/f7c6191f9740/d5ra00619h-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/d4293cb3bfd2/d5ra00619h-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/92bef7d01521/d5ra00619h-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/aef18522aa78/d5ra00619h-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/07642a101340/d5ra00619h-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/cc7bde75cc45/d5ra00619h-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/131964f4b94b/d5ra00619h-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4580a759cc5f/d5ra00619h-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c4c3724feeae/d5ra00619h-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/790935c5822a/d5ra00619h-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/55b4a3568474/d5ra00619h-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/bcd4081ff089/d5ra00619h-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4f49770f52b7/d5ra00619h-s24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/4ee2d7f2e289/d5ra00619h-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/b37eabc9efe2/d5ra00619h-s26.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/80d18ef1410d/d5ra00619h-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/c2a370973253/d5ra00619h-s28.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/663404ca6676/d5ra00619h-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/34826a801001/d5ra00619h-s30.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/0d20f8f7e52d/d5ra00619h-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb4f/11912353/3195a0862cde/d5ra00619h-s32.jpg

相似文献

1
Corey-Fuchs reaction enabled synthesis of natural products: a review.科里-富克斯反应助力天然产物的合成：综述
RSC Adv. 2025 Mar 17;15(11):8121-8155. doi: 10.1039/d5ra00619h.
2
The Corey-Seebach Reagent in the 21st Century: A Review.《21 世纪的 Corey-Seebach 试剂：综述》。
Molecules. 2023 May 26;28(11):4367. doi: 10.3390/molecules28114367.
3
Novel Bioactive Natural Products from Marine-Derived Fungi: A Review (2021-2023).海洋源真菌来源的新型生物活性天然产物：综述（2021-2023 年）。
Mar Drugs. 2024 Apr 23;22(5):191. doi: 10.3390/md22050191.
4
Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues.向山羟醛反应：一种获取手性天然产物及其衍生物/类似物的有效不对称方法。
RSC Adv. 2023 Nov 8;13(47):32975-33027. doi: 10.1039/d3ra05058k. eCollection 2023 Nov 7.
5
Electrochemically modified Corey-Fuchs reaction for the synthesis of arylalkynes. The case of 2-(2,2-dibromovinyl)naphthalene.用于合成芳基炔烃的电化学修饰的科里-富克斯反应。以2-(2,2-二溴乙烯基)萘为例。
Beilstein J Org Chem. 2018 Apr 23;14:891-899. doi: 10.3762/bjoc.14.76. eCollection 2018.
6
A Case for Bond-Network Analysis in the Synthesis of Bridged Polycyclic Complex Molecules: Hetidine and Hetisine Diterpenoid Alkaloids.桥连多环复杂分子合成中的键网络分析实例：野百合碱和野百合次碱二萜生物碱。
Angew Chem Int Ed Engl. 2020 Jun 26;59(27):10722-10731. doi: 10.1002/anie.201909656. Epub 2020 Apr 15.
7
Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review.Mitsunobu 反应：一种用于天然产物合成的有力工具：综述。
Molecules. 2022 Oct 17;27(20):6953. doi: 10.3390/molecules27206953.
8
Major bioactive metabolites from marine fungi: A Review.海洋真菌的主要生物活性代谢产物：综述
Bioinformation. 2015 Apr 30;11(4):176-81. doi: 10.6026/97320630011176. eCollection 2015.
9
Baeyer-Villiger oxidation: a promising tool for the synthesis of natural products: a review.拜耳-维立格氧化反应：一种用于天然产物合成的有前景的工具：综述
RSC Adv. 2024 Jul 25;14(32):23423-23458. doi: 10.1039/d4ra03914a. eCollection 2024 Jul 19.
10
Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery.植物源抗肿瘤天然产物的发现：抗肿瘤药物发现的潜在先导物。
Bioorg Chem. 2024 Jan;142:106957. doi: 10.1016/j.bioorg.2023.106957. Epub 2023 Nov 4.

本文引用的文献

1
Transition metal-catalyzed cross-coupling reactions of -aryl-2-aminopyridines.-芳基-2-氨基吡啶的过渡金属催化交叉偶联反应
RSC Adv. 2025 Jan 14;15(2):1134-1151. doi: 10.1039/d4ra08384a. eCollection 2025 Jan 9.
2
Chemoselective Preparation of Alkynes from Vicinal and Geminal Dibromoalkenes.由邻二溴烯烃和偕二溴烯烃化学选择性制备炔烃
Org Lett. 2024 Nov 22;26(46):9817-9821. doi: 10.1021/acs.orglett.4c03483. Epub 2024 Nov 9.
3
Asymmetric Total Synthesis of Naturally Occurring ()-2'-Methoxydihydroartemidin, ()-()-3'-Hydroxyartemidin, and Its Structural Congeners: Method Optimization and Mechanistic Analysis.
天然存在的（）-2'-甲氧基二氢青蒿素、（）-（）-3'-羟基青蒿素及其结构类似物的不对称全合成：方法优化与机理分析
J Org Chem. 2024 Nov 1;89(21):15764-15776. doi: 10.1021/acs.joc.4c01868. Epub 2024 Oct 18.
4
Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi. Fusaramin 的全合成，实现立体化学阐明、构效关系研究以及揭示对植物病原真菌的隐藏抗菌活性。
Org Lett. 2024 Jan 26;26(3):597-601. doi: 10.1021/acs.orglett.3c03792. Epub 2024 Jan 10.
5
Concise total synthesis and structure revision of metacridamides A and B.间吖啶酰胺A和B的简洁全合成及结构修正
Chem Commun (Camb). 2023 Aug 10;59(65):9880-9883. doi: 10.1039/d3cc01694c.
6
In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of Polyketide Synthase 13.新型苯并呋喃-1,3,4-恶二唑作为聚酮合酶13潜在抑制剂的计算机辅助开发
Pharmaceuticals (Basel). 2023 Jun 1;16(6):829. doi: 10.3390/ph16060829.
7
Structure-Based Virtual Screening of Furan-1,3,4-Oxadiazole Tethered -phenylacetamide Derivatives as Novel Class of hTYR and hTYRP1 Inhibitors.基于结构的呋喃-1,3,4-恶二唑连接的苯基乙酰胺衍生物作为新型hTYR和hTYRP1抑制剂的虚拟筛选
Pharmaceuticals (Basel). 2023 Feb 23;16(3):344. doi: 10.3390/ph16030344.
8
Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review.Sharpless 不对称双羟化反应：天然产物合成的杰出工具——综述
Molecules. 2023 Mar 17;28(6):2722. doi: 10.3390/molecules28062722.
9
Stereocontrolled total synthesis of Resolvin D4 and 17()-Resolvin D4.立体选择性全合成 Resolvin D4 和 17()-Resolvin D4。
Org Biomol Chem. 2023 Feb 22;21(8):1667-1673. doi: 10.1039/d2ob01697d.
10
Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review.Mitsunobu 反应：一种用于天然产物合成的有力工具：综述。
Molecules. 2022 Oct 17;27(20):6953. doi: 10.3390/molecules27206953.