Mitsunobu 反应：一种用于天然产物合成的有力工具：综述。

Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.

College of Agriculture and Environmental Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan.

Molecules. 2022 Oct 17;27(20):6953. doi: 10.3390/molecules27206953.

The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years.

Mitsunobu 反应在有机化学中起着至关重要的作用，因为它具有广泛的合成应用。它被认为是一种重要的反应，可以在氧化剂（偶氮二甲酸酯）和还原剂（膦）存在下将一个官能团（醇）转化为另一个官能团（酯）。它是一种著名的立体选择性反应，会反转产物的立体化学构型。Mitsunobu 反应最重要的应用之一是在天然产物的合成中的作用。本文综述将重点介绍 Mitsunobu 反应在天然产物全合成中的贡献，强调近年来它们的生物潜力。