Hafed Ziad M
Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
iScience. 2025 Feb 13;28(3):112021. doi: 10.1016/j.isci.2025.112021. eCollection 2025 Mar 21.
The primate superior colliculus (SC) plays important sensory, cognitive, and motor processing roles. Among its properties, the SC has clear visual field asymmetries: visual responses are stronger in the upper visual field representation, whereas saccade-related motor bursts are weaker. Here, I asked whether peri-saccadic SC network activity can still reflect the SC's visual sensitivity asymmetry, thus supporting recent evidence of sensory-related signals embedded within the SC's motor bursts. I analyzed collicular peri-saccadic local field potential (LFP) modulations and found them to be much stronger in the upper visual field, despite the weaker motor bursts. This effect persisted even with saccades toward a blank, suggesting an importance of visual field location. I also found that engaging working memory during saccade preparation differentially modulated the SC's LFP's, again with a dichotomous upper/lower visual field asymmetry. I conclude that the SC network possesses a clear sensory signal at the time of saccade generation.
灵长类动物的上丘（SC）在感觉、认知和运动处理中发挥着重要作用。在其特性中，上丘具有明显的视野不对称性：在视野上部表征中的视觉反应更强，而与扫视相关的运动爆发则较弱。在此，我探讨了扫视周围上丘网络活动是否仍能反映上丘的视觉敏感性不对称性，从而支持最近关于嵌入在上丘运动爆发中的感觉相关信号的证据。我分析了上丘扫视周围局部场电位（LFP）调制，发现尽管运动爆发较弱，但它们在视野上部要强得多。即使扫视到空白处，这种效应仍然存在，表明视野位置的重要性。我还发现，在扫视准备期间运用工作记忆对上丘的LFP有不同的调制作用，同样存在上下视野二分的不对称性。我得出结论，上丘网络在扫视产生时具有清晰的感觉信号。
