Wu Weibing, Xu Jingjing, Ruan Jianling, Tian Baoping, Xuan Nanxia
Department of Critical Care Medicine, Qingyuan People's Hospital, Lishui, China.
Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Front Cardiovasc Med. 2025 Mar 4;12:1487543. doi: 10.3389/fcvm.2025.1487543. eCollection 2025.
Aspergillus endocarditis is a rare but highly fatal condition, particularly in immunocompromised patients. This case report describes a 74-year-old male with native valve Aspergillus fumigatus endocarditis and intracranial infection. Diagnosis was complicated by atypical presentation and negative blood cultures, but metagenomic next-generation sequencing (mNGS) enabled rapid identification of the pathogen. This case is notable for being the first to document Aspergillus fumigatus endocarditis with cerebral involvement confirmed by mNGS, highlighting the importance of early diagnosis and advanced diagnostic tools in improving outcomes.
曲霉性心内膜炎是一种罕见但致死率极高的疾病，在免疫功能低下的患者中尤为如此。本病例报告描述了一名74岁男性患有天然瓣膜烟曲霉性心内膜炎及颅内感染。诊断因非典型表现和血培养阴性而复杂化，但宏基因组下一代测序（mNGS）能够快速鉴定病原体。该病例值得注意的是，它是首例经mNGS证实有脑部累及的烟曲霉性心内膜炎，凸显了早期诊断和先进诊断工具对改善预后的重要性。
