Radmilović Goranka, Popović-Grle Sanja, Matijević Valentina
Daruvarske toplice Special Hospital for Medical Rehabilitation, Daruvar, Croatia, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Jordanovac Department for Lung Diseases, Zagreb University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2024 Oct;63(2):316-325. doi: 10.20471/acc.2024.63.02.7.
Smoking is a major risk factor for the development of chronic obstructive pulmonary disease (COPD), which is thought to be caused by smoking in even 8 out of 10 cases. One of the first clinical signs in patients with COPD is reduced physical ability, which is usually attributed to reduced lung function, although a significant role is played by a disorder of the musculoskeletal system. The aim of the study was to examine differences in fitness and locomotor status between smokers and non-smokers, as well as the effect of oral administration of L-arginine on the strength of the quadriceps depending on smoking status. The study included 164 subjects, 84 non-smokers and 81 smokers not diagnosed with COPD. All subjects completed CAT and IPAQ questionnaires, and performed spirometry, 6-minute walking test and quadriceps strength testing without therapy and after oral administration of 500 mg L-arginine. The results showed that the increase in quadriceps strength after oral administration of L-arginine was not dependent on smoking status but was more pronounced in smokers who started smoking at an earlier age and who smoked more cigarettes, as well as a generally higher physical activity of non-smokers. These results could become relevant for recognizing the development of skeletal musculature hypotonus and hypotrophy in smokers who are prone to develop COPD.
吸烟是慢性阻塞性肺疾病（COPD）发病的主要危险因素，在10例病例中，甚至有8例被认为是由吸烟引起的。COPD患者最早出现的临床症状之一是身体能力下降，这通常归因于肺功能下降，尽管肌肉骨骼系统紊乱也起着重要作用。本研究的目的是检查吸烟者和非吸烟者在体能和运动状态方面的差异，以及口服L-精氨酸对股四头肌力量的影响（取决于吸烟状态）。该研究纳入了164名受试者，其中84名非吸烟者和81名未被诊断为COPD的吸烟者。所有受试者均完成了CAT和IPAQ问卷，并在未接受治疗以及口服500毫克L-精氨酸后进行了肺活量测定、6分钟步行试验和股四头肌力量测试。结果表明，口服L-精氨酸后股四头肌力量的增加并不取决于吸烟状态，但在吸烟起始年龄较早、吸烟量较大的吸烟者中更为明显，同时非吸烟者的总体身体活动水平通常更高。这些结果可能有助于识别易患COPD的吸烟者中骨骼肌张力减退和萎缩的发展情况。
