Atlihan Ufuk, Durakli Ulukök Meltem, Yavuz Onur
Department of Gynecology and Obstetrics, Private Karataş Hospital, İzmir, Turkiye.
Department of Neurology, Private Cankaya Medical Center, İzmir, Turkiye.
Turk J Med Sci. 2024 Dec 5;55(1):258-264. doi: 10.55730/1300-0144.5966. eCollection 2025.
BACKGROUND/AIM: To evaluate the relationship between the change in pain intensity over days of the menstrual cycle and cognitive function in females with primary dysmenorrhea.
One hundred thirty-four females with primary dysmenorrhea who were admitted to our hospital from January 2021 to November 2023 were assessed. Of these participants, 46 individuals who subjectively stated that their cognitive function was affected, for whom neurology consultation was requested, and for whom patient data were available, were included in the study.
A significant decrease was seen in phonemic and semantic fluency on day 3 of menstruation (p < 0.001 and p < 0.001, respectively). A significant decrease was observed in the forward and backward digit span (DGS) scores on day 3 of menstruation (p < 0.001 and p < 0.001, respectively). A significant decrease was seen in the forward and backward DGS scores on the most painful day of menstruation (p < 0.001 and p < 0.001, respectively). A significant decrease in the logical memory subtest Wechsler Memory Scale revised scores on the most painful day of menstruation (p < 0.001).
Consistent with the literature, strong evidence was found showing a negative correlation between dysmenorrhea and cognitive function. Future prospective, larger sample-size studies comparing cognitive function in females with and without dysmenorrhea at various stages of the menstrual cycle are needed.
背景/目的：评估原发性痛经女性在月经周期各天疼痛强度变化与认知功能之间的关系。
对2021年1月至2023年11月期间我院收治的134例原发性痛经女性进行评估。在这些参与者中，46名主观表示其认知功能受到影响、已请求神经科会诊且有患者数据的个体被纳入研究。
月经第3天，音素流畅性和语义流畅性显著下降（分别为p < 0.001和p < 0.001）。月经第3天，顺背和倒背数字广度（DGS）得分显著下降（分别为p < 0.001和p < 0.001）。月经最疼痛那天，顺背和倒背DGS得分显著下降（分别为p < 0.001和p < 0.001）。月经最疼痛那天，韦氏记忆量表修订版逻辑记忆子测试得分显著下降（p < 0.001）。
与文献一致，有力证据表明痛经与认知功能之间存在负相关。未来需要进行前瞻性、更大样本量的研究，比较月经周期不同阶段有痛经和无痛经女性的认知功能。
