Yang Zijie, Chen Jiachun, Wei Lan, Dai Delei, Tang Hu, Zhang Yan, Xie Wei, Liu Shaochu, Tan Wei, Shi Xiangdong, Zheng Chenli, Yuan Xiaohong, Xu Zhongliang, Ye Wei, Zhao Jin
STD & AIDS Control and Prevention Section, Shenzhen Center for Disease Control and Prevention, Shenzhen City, Guangdong Province, China.
School of Public Health, Peking University, Beijing, China.
China CDC Wkly. 2025 Feb 21;7(8):277-282. doi: 10.46234/ccdcw2025.044.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) have been proven effective in preventing human immunodeficiency virus (HIV) transmission.
WHAT IS ADDED BY THIS REPORT?: Men who have sex with men (MSM) who incorrectly used PrEP/PEP demonstrated higher HIV positivity rates compared to both correct users and non-users. Since PrEP/PEP users are more likely to engage in unprotected anal intercourse (UAI), incorrect use of these prophylactic measures may constitute a significant risk factor for HIV transmission among MSM.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: It is crucial to implement strategies that guide MSM toward correct PrEP/PEP utilization while emphasizing that these prophylactic measures should not be considered substitutes for condom use.
关于该主题已知的信息有哪些？：暴露前预防（PrEP）和暴露后预防（PEP）已被证明在预防人类免疫缺陷病毒（HIV）传播方面有效。
本报告新增了哪些内容？：与正确使用者和未使用者相比，男男性行为者（MSM）中PrEP/PEP使用不当者的HIV阳性率更高。由于PrEP/PEP使用者更有可能进行无保护肛交（UAI），这些预防措施使用不当可能构成男男性行为者中HIV传播的一个重要风险因素。
对公共卫生实践有哪些影响？：实施引导男男性行为者正确使用PrEP/PEP的策略至关重要，同时要强调这些预防措施不应被视为避孕套使用的替代品。
