Szakmany Tamas, Bailey Rowena, Griffiths Rowena, Pugh Richard, Hollinghurst Joe, Akbari Ashley, Lyons Ronan A
Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK.
Critical Care Directorate, Grange University Hospital, Aneurin Bevan University Health Board, Cwmbran, UK.
J Intensive Care Soc. 2025 Mar 16:17511437251326774. doi: 10.1177/17511437251326774.
We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.
We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006-2018, with an inpatient admission including one or more explicit sepsis codes.
38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients with high levels of comorbidities, but changes were consistent across all age groups, areas of deprivation and ICU admissions. Estimated inpatient sepsis costs were £340.34 million in total during the study period. The average cost per hospital spell was £7270. Patients readmitted to the hospital for sepsis amassed estimated treatment costs of over £72 million during the study period. Out of the 38,564 persons, 21,275 (55.2%) died within 3 years of their first admission. Inpatient mortality halved from 40.5% to 19.5%, and there was a trend towards reduced mortality at 6 months, 1 and 3 years post hospital discharge.
Sepsis related hospital admissions are increasing over time and still likely to be underreported. Although mortality appears to have fallen, prolonged hospitalisation and readmissions place a significant burden on healthcare system resources and costs.
我们评估了英国威尔士成年住院患者败血症的医疗保健和经济负担。
我们通过安全匿名信息链接数据库分析了威尔士所有急症医院的住院情况。纳入了2006年至2018年期间所有成年患者，其住院记录包含一个或多个明确的败血症编码。
2006年至2018年期间，38564名患者至少有一次因败血症入院。大多数人（86.7%）仅有一次入院。3398名患者（8.4%）入住了重症监护病房。在研究期间，入院人数逐年增加，从2006年的1548人增至2018年的8708人。最大的年度增幅（较上一年增长141.7%）出现在2017年。合并症程度高的患者入院人数增长不成比例，但所有年龄组、贫困地区和重症监护病房入院患者的变化趋势一致。研究期间，败血症住院总费用估计为3.4034亿英镑。每次住院的平均费用为7270英镑。在研究期间，因败血症再次入院的患者累计估计治疗费用超过7200万英镑。在38564人中，21275人（55.2%）在首次入院后3年内死亡。住院死亡率从40.5%降至19.5%，出院后6个月、1年和3年的死亡率有下降趋势。
与败血症相关的住院人数随时间增加，且可能仍有漏报情况。尽管死亡率似乎有所下降，但延长的住院时间和再次入院给医疗系统资源和成本带来了巨大负担。
