Min Kyung Hyun, Kim Jun Hyeob, Gil Jin Yeon, Park Jun Hyuk, Han Ji Min, Lee Kyung Eun
College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
Epidemiol Infect. 2025 Mar 19;153:e51. doi: 10.1017/S0950268825000329.
The study aimed to delve into the incidence and risk factors associated with myocarditis and pericarditis following SARS-COV-2-19 vaccination, addressing a notable gap in understanding the safety profile of vaccinations. Through meticulous data selection from the National Health Insurance System (NHIS) database of Korea, the researchers employed both a case-crossover study and a nested case-control design to analyze temporal patterns and risk factors related to carditis occurrences post-immunization. Key findings revealed a significant association between SARS-COV-2-19 vaccination and the occurrence of carditis, with a strong temporal correlation observed within 10 days post-vaccination. Noteworthy factors contributing to carditis risk included the duration between vaccination and carditis, specific comorbidities and medication use. The study concluded by recommending an extended post-vaccination surveillance duration of at least 10 days and underscored the importance of considering individual medical histories and concurrent medication use in assessing vaccine-induced carditis risk. This study might contribute to understanding vaccine safety profiles and emphasizes the significance of comprehensive post-vaccination monitoring protocols.
该研究旨在深入探究接种新型冠状病毒2019疫苗（SARS-COV-2-19疫苗）后心肌炎和心包炎的发病率及相关风险因素，以填补在了解疫苗安全性方面的显著空白。通过从韩国国民健康保险系统（NHIS）数据库中精心挑选数据，研究人员采用病例交叉研究和巢式病例对照设计，分析免疫接种后与心脏炎发生相关的时间模式和风险因素。主要研究结果显示，接种SARS-COV-2-19疫苗与心脏炎的发生之间存在显著关联，在接种疫苗后10天内观察到强烈的时间相关性。导致心脏炎风险的值得注意的因素包括接种疫苗与心脏炎之间的时间间隔、特定的合并症和药物使用情况。该研究通过建议将接种疫苗后的监测期延长至至少10天得出结论，并强调在评估疫苗诱导的心脏炎风险时考虑个人病史和同时使用的药物的重要性。这项研究可能有助于了解疫苗的安全性概况，并强调全面的接种后监测方案的重要性。
