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谁在诊断儿童甲状腺结节?一家三级儿童医院的回顾。

Who Is Diagnosing Pediatric Thyroid Nodules? A Tertiary Children's Hospital Review.

作者信息

Justice Joy M, Sethurathnam Janavi, Nayak Nanda, Chen Heidi, Patel Kalpnaben, Bartz Sara, Baron Christopher, Patterson Barron, Belcher Ryan H

机构信息

Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Vanderbilt University Department of Biostatistics, Nashville, Tennessee, USA.

出版信息

Otolaryngol Head Neck Surg. 2025 Jul;173(1):251-259. doi: 10.1002/ohn.1232. Epub 2025 Mar 19.

Abstract

OBJECTIVE

The incidence of pediatric thyroid cancer has increased. Little is documented about which providers are diagnosing pediatric thyroid nodules and how this impacts care. Our objective was to analyze how nodules are identified and how diagnosing provider type impacts nodule size and management.

STUDY DESIGN

Retrospective chart review.

SETTING

Tertiary care children's hospital.

METHODS

Pediatric patients (aged 0-17) with at least one thyroid nodule diagnosed between 2006 and 2023 were reviewed. Diagnosing provider type, diagnostic method, nodule size, clinical management, and final diagnosis were analyzed.

RESULTS

The study included 351 patients. Primary care providers diagnosed the largest proportion of nodules (43.0%), followed by incidental nodules by radiologists (24.2%). The proportion diagnosed by radiologists increased from 12% to 31% after 2017 (P < .001). Primary care providers were more likely to use physical exam than pediatric endocrinologists (65% vs 42%, P = .004), who more often used ultrasound (56% vs 37%, P = .02). Primary care providers diagnosed nodules with a median diameter of 1.50 cm, larger than that of pediatric endocrinologists and radiologists, both 0.8 cm (P = .01, P < .001). Compared to patients diagnosed by radiologists, patients diagnosed by primary care providers more often underwent biopsy (P = .02) or surgery (P < .001) and received a malignant diagnosis (P = .001).

CONCLUSION

Primary care providers play a key role in detecting pediatric thyroid nodules, and a physical exam is vital in identifying significant pathology. Radiologic incidental nodules increased in frequency over our study timespan. Future research should consider the impact of socioeconomic status or geographic location on nodule size and management.

摘要

目的

儿童甲状腺癌的发病率有所上升。关于哪些医疗服务提供者诊断儿童甲状腺结节以及这如何影响治疗,相关记录较少。我们的目的是分析甲状腺结节是如何被识别的,以及诊断医疗服务提供者的类型如何影响结节大小和治疗。

研究设计

回顾性病历审查。

研究地点

三级护理儿童医院。

方法

对2006年至2023年间诊断出至少有一个甲状腺结节的儿科患者(0至17岁)进行审查。分析诊断医疗服务提供者的类型、诊断方法、结节大小、临床治疗及最终诊断。

结果

该研究纳入了351名患者。初级保健提供者诊断出的结节比例最高(43.0%),其次是放射科医生偶然发现的结节(24.2%)。2017年后,放射科医生诊断出的比例从12%增至31%(P < 0.001)。与儿科内分泌学家相比,初级保健提供者更可能使用体格检查(65%对42%,P = 0.004),而儿科内分泌学家更常使用超声检查(56%对37%,P = 0.02)。初级保健提供者诊断出的结节中位直径为1.50厘米,大于儿科内分泌学家和放射科医生诊断出的结节,后两者均为0.8厘米(P = 0.01,P < 0.001)。与放射科医生诊断的患者相比,初级保健提供者诊断的患者更常接受活检(P = 0.02)或手术(P < 0.001),且被诊断为恶性的比例更高(P = 0.001)。

结论

初级保健提供者在检测儿童甲状腺结节方面发挥着关键作用,体格检查对于识别重大病变至关重要。在我们的研究时间段内,放射学偶然发现的结节频率有所增加。未来的研究应考虑社会经济地位或地理位置对结节大小和治疗的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/12207357/5b43fe325a2f/OHN-173-251-g003.jpg

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