Norman A, Bass D, Roe D
Mutat Res. 1985 Jul;143(3):155-60. doi: 10.1016/s0165-7992(85)80027-0.
In order to determine the usefulness of micronuclear counts (MNC) for identifying people with relatively high frequencies of chromosome aberrations we have examined factors that influence the MNC in a learning set of blood samples obtained from 28 adults. The presence of cells with chromosome aberrations among approximately 170 metaphase cells per sample was the most important factor. Controlling for the effect of chromosome aberrations we found that age had a significant effect on MNC, but that donor sex, the mitotic index, the per cent of metaphase cells in the second or third division or the frequency of abnormal anaphase cells did not. Using logistic regression analysis we found that MNC was an excellent predictor of the presence of cells with chromosome aberrations among both the learning set and a test set of 17 additional blood samples.
为了确定微核计数（MNC）在识别染色体畸变频率相对较高的人群中的有用性，我们研究了影响28名成年人血液样本学习集中MNC的因素。每个样本约170个中期细胞中存在染色体畸变细胞是最重要的因素。在控制染色体畸变的影响后，我们发现年龄对MNC有显著影响，但供体性别、有丝分裂指数、第二或第三次分裂中期细胞百分比或后期异常细胞频率没有影响。使用逻辑回归分析，我们发现MNC是学习集和另外17份血液样本测试集中存在染色体畸变细胞的优秀预测指标。
