一种对颗粒携带化学物质的诱变敏感的人类细胞系。
A human cell line sensitive to mutation by particle-borne chemicals.
作者信息
Crespi C L, Liber H L, Behymer T D, Hites R A, Thilly W G
出版信息
Mutat Res. 1985 Jul;157(1):71-5. doi: 10.1016/0165-1218(85)90051-5.
PMID:4010699
Abstract
A human lymphoblastoid cell line with ability to perform oxidative metabolism of various chemicals is mutated by the direct addition of an intact particulate soot. This experiment demonstrates that materials associated with combustion-generated particulates are biologically available and able to cause genetic changes in metabolically competent human cells.
摘要
一种具有对多种化学物质进行氧化代谢能力的人淋巴母细胞系，通过直接添加完整的颗粒状煤烟而发生突变。该实验表明，与燃烧产生的颗粒物相关的物质具有生物可利用性，并且能够在具有代谢活性的人类细胞中引起基因变化。
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