Zhou Zhong-Yu, Liu Ji-Sheng, Gao Ri, Jin Xin-Mei, Xiu Jing-Run, Jin Mei-Yu, Yu Shuo, Piao Xuan-Chun, Lian Mei-Lan
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Park Road 977, Yanji, Jilin, 133002, China.
Yanbian Academy of Agricultural Sciences, Longjing, Jilin, 133400, China.
J Ethnopharmacol. 2025 Apr 25;346:119650. doi: 10.1016/j.jep.2025.119650. Epub 2025 Mar 17.
Oplopanax elatus Nakai is a valuable medicinal plant of the Araliaceae family. In China, South Korea, and Russia, O. elatus has a long history of ethnomedical use, particularly for treating neurasthenia, schizophrenia, cardiovascular disease, and other conditions. However, its commercial use is hindered by the scarcity of raw materials, largely due to the depletion of wild resources and the underdeveloped technology for artificial cultivation. Although reviews on O. elatus exist, they lack coverage of recent research advances and fail to address all relevant aspects. Therefore, a comprehensive understanding of current research on this species is crucial for its future applications.
This paper aims to provide a comprehensive overview of the current state of research on O. elatus and to integrate recent findings that will guide future research and promote the sustainable utilization of this valuable medicinal plant.
Available information was collected from scientific databases, including Google Scholar, Web of Science, PubMed, ScienceDirect, Baidu Scholar, China National Knowledge Infrastructure, and Ethnobotanical Monographs. A comprehensive literature on traditional use, phytochemistry, pharmacology, pharmacokinetics, quality control, and toxicity published before June 2024. The findings were summarized in this paper.
This paper provided a comprehensive review of the research progress on O. elatus, covering its resource status, propagation, phytochemistry, pharmacology, pharmacokinetics, quality control, and toxicity. Previous studies were summarized and current results were presented. In addition, existing challenges, such as the lack of research on quality control and molecular biology, were highlighted, along with potential approaches to address these issues. Finally, the future development prospects and potential applications of O. elatus were discussed.
O. elatus has significant potential for use in the production of medicinal, functional foods, and cosmetic products. In particular, adventitious root culture could address the current resource challenges associated with O. elatus and facilitate product development and production. However, further research in quality control and molecular biology is required to fully realize its potential.
刺人参是五加科一种珍贵的药用植物。在中国、韩国和俄罗斯，刺人参有着悠久的民族医学应用历史，尤其用于治疗神经衰弱、精神分裂症、心血管疾病和其他病症。然而，其商业用途受到原材料稀缺的阻碍，这主要是由于野生资源的枯竭以及人工栽培技术的不发达。尽管存在关于刺人参的综述，但它们缺乏对近期研究进展的涵盖，并且未能涉及所有相关方面。因此，全面了解该物种的当前研究对于其未来应用至关重要。
本文旨在全面概述刺人参的当前研究状况，并整合近期研究结果，以指导未来研究并促进这种珍贵药用植物的可持续利用。
从科学数据库收集可用信息，包括谷歌学术、科学网、PubMed、ScienceDirect、百度学术、中国知网和民族植物学专著。收集了截至2024年6月之前发表的关于传统用途、植物化学、药理学、药代动力学、质量控制和毒性的综合文献。本文对研究结果进行了总结。
本文对刺人参的研究进展进行了全面综述，涵盖其资源状况、繁殖、植物化学、药理学、药代动力学、质量控制和毒性。总结了先前的研究并展示了当前的结果。此外，突出了现有挑战，如质量控制和分子生物学方面缺乏研究，以及解决这些问题的潜在方法。最后，讨论了刺人参的未来发展前景和潜在应用。
刺人参在药用、功能性食品和化妆品生产中具有巨大潜力。特别是，不定根培养可以解决当前与刺人参相关的资源挑战，并促进产品开发和生产。然而，需要在质量控制和分子生物学方面进行进一步研究，以充分实现其潜力。
