Hua Tianchi, Zheng Shengqi, Ding Jiawen, Geng Zhaoyong, Zhang Wei, Qi Tingyue, Li Yifan, Wang Xiaoxiang
Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China
BMJ Open. 2025 Mar 18;15(3):e092844. doi: 10.1136/bmjopen-2024-092844.
Serum uric acid (SUA), a non-protein antioxidant, exerts anti-inflammatory and antioxidative stress effects. This study aimed to investigate the association between SUA levels and the risk of benign prostatic hyperplasia (BPH).
This cross-sectional study included 48 653 adult men who underwent health checkups at the Health Examination Center of the Affiliated Hospital of Yangzhou University in 2022. Data on demographics, clinical history and laboratory parameters were collected. Multivariable logistic regression models were used to analyse the relationship between SUA levels and BPH risk, with further exploration in different subgroups.
Logistic regression analysis revealed a significantly decreased risk of BPH among participants in the highest SUA quartile (Q4) compared with those in the lowest quartile (Q1) (fully adjusted OR=0.83, 95% CI: 0.78 to 0.90, p<0.0001). Subgroup analyses demonstrated that this inverse association was more pronounced in subgroups of age>60 years (Q4: OR=0.77, 95% CI: 0.68 to 0.87, p<0.0001), non-obesity (Q4: OR=0.81, 95% CI: 0.75 to 0.87, p<0.0001), without non-alcoholic fatty liver disease (NAFLD) (Q4: OR=0.81, 95% CI: 0.73 to 0.89, p<0.0001), hypertension (Q4: OR=0.81, 95% CI: 0.74 to 0.89, p<0.0001) and without diabetes (Q4: OR=0.84, 95% CI: 0.78 to 0.90, p<0.0001). Curve fitting revealed that higher SUA levels were associated with a lower risk of BPH even in the presence of increased BPH risk factors such as diabetes and hypertension.
This study demonstrates a significant inverse association between SUA levels and BPH risk, particularly in subgroups of older age, non-obesity, absence of NAFLD, hypertension and absence of diabetes. This suggests a potential protective role of SUA in BPH development, highlighting the potential value of maintaining SUA levels within a reasonable range for BPH prevention.
血清尿酸（SUA）作为一种非蛋白质抗氧化剂，具有抗炎和抗氧化应激作用。本研究旨在探讨SUA水平与良性前列腺增生（BPH）风险之间的关联。
这项横断面研究纳入了2022年在扬州大学附属医院健康体检中心接受健康检查的48653名成年男性。收集了人口统计学、临床病史和实验室参数数据。采用多变量逻辑回归模型分析SUA水平与BPH风险之间的关系，并在不同亚组中进行进一步探索。
逻辑回归分析显示，与最低四分位数（Q1）的参与者相比，最高SUA四分位数（Q4）的参与者患BPH的风险显著降低（完全调整后的OR=0.83，95%CI：0.78至0.90，p<0.0001）。亚组分析表明，这种负相关在年龄>60岁（Q4：OR=0.77，95%CI：0.68至0.87，p<0.0001）、非肥胖（Q4：OR=0.81，95%CI：0.75至0.87，p<0.0001）、无非酒精性脂肪性肝病（NAFLD）（Q4：OR=0.81，95%CI：0.73至0.89，p<0.0001）、高血压（Q4：OR=0.81，95%CI：0.74至0.89，p<0.0001）和无糖尿病（Q4：OR=0.84，95%CI：0.78至0.90，p<0.0001）的亚组中更为明显。曲线拟合显示，即使存在糖尿病和高血压等增加BPH风险的因素，较高的SUA水平也与较低的BPH风险相关。
本研究表明SUA水平与BPH风险之间存在显著的负相关，尤其是在老年、非肥胖、无NAFLD、高血压和无糖尿病的亚组中。这表明SUA在BPH发生发展中可能具有保护作用，强调了将SUA水平维持在合理范围内对预防BPH的潜在价值。
