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Structural characterization reveals substrate recognition by the taurine transporter TauT.

作者信息

Xu Hao, Bai Qinru, Wang Han, Zhao Jun, Guo Aiping, Li Renjie, Chen Qihao, Wei Yiqing, Li Na, Huang Zhuo, Zhao Yan

机构信息

Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Discov. 2025 Mar 20;11(1):28. doi: 10.1038/s41421-025-00785-1.

DOI:10.1038/s41421-025-00785-1
PMID:40108165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11923213/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff2c/11923213/bad528b1da93/41421_2025_785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff2c/11923213/bad528b1da93/41421_2025_785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff2c/11923213/bad528b1da93/41421_2025_785_Fig1_HTML.jpg

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Transport and inhibition mechanisms of the human noradrenaline transporter.人去甲肾上腺素转运体的转运和抑制机制。
Nature. 2024 Aug;632(8026):930-937. doi: 10.1038/s41586-024-07638-z. Epub 2024 Jul 31.
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Transport mechanism and pharmacology of the human GlyT1.人 GlyT1 的转运机制和药理学。
Cell. 2024 Mar 28;187(7):1719-1732.e14. doi: 10.1016/j.cell.2024.02.026. Epub 2024 Mar 20.
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Molecular basis for substrate recognition and transport of human GABA transporter GAT1.人 GABA 转运蛋白 GAT1 的底物识别和转运的分子基础。
Nat Struct Mol Biol. 2023 Jul;30(7):1012-1022. doi: 10.1038/s41594-023-00983-z. Epub 2023 Jul 3.
5
Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency.牛磺酸治疗 SLC6A6 牛磺酸转运体缺陷的近亲家系中的视网膜变性和心肌病。
Hum Mol Genet. 2020 Mar 13;29(4):618-623. doi: 10.1093/hmg/ddz303.
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Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.SLC6A6 表达水平升高可促进胃癌发生发展并影响临床结局。
Biomark Med. 2019 Feb;13(2):95-104. doi: 10.2217/bmm-2018-0256. Epub 2019 Feb 15.
7
Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line.鉴定人源牛磺酸转运蛋白 TauT 的竞争性抑制剂在人肾细胞系中的应用。
Pharmacol Rep. 2019 Feb;71(1):121-129. doi: 10.1016/j.pharep.2018.10.005. Epub 2018 Oct 24.
8
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.γ-氨基丁酸模拟物与高渗处理的Caco-2细胞、LLC-PK1细胞及大鼠肾SKPT细胞中牛磺酸转运体（TauT，Slc6a6）的相互作用
Eur J Pharm Sci. 2016 Jan 20;82:138-46. doi: 10.1016/j.ejps.2015.11.020. Epub 2015 Nov 26.
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The solute carrier 6 family of transporters.溶质载体 6 家族转运蛋白。
Br J Pharmacol. 2012 Sep;167(2):256-78. doi: 10.1111/j.1476-5381.2012.01975.x.
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