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二氧化硅纳米颗粒和氧化石墨烯纳米片复合修饰的ZIF-67电极用于对乙酰氨基酚和双氯芬酸的同时测定

ZIF-67 decorated with silica nanoparticles and graphene oxide nanosheets composite modified electrode for simultaneous determination of paracetamol and diclofenac.

作者信息

Habibi Biuck, Bahadori Younes, Pashazadeh Sara, Pashazadeh Ali

机构信息

Electroanalytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, 53714-161, Iran.

出版信息

Sci Rep. 2025 Mar 19;15(1):9499. doi: 10.1038/s41598-025-94178-9.

DOI:10.1038/s41598-025-94178-9
PMID:40108259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11923285/
Abstract

In this work, a novel nanocomposite containing zeolitic imidazolate framework-67 decorated silica nanoparticles/graphene oxide nanosheets (ZIF-67/SiONPs/GONs) was synthesized and used for the fabrication of the modified glassy carbon electrode for individual and simultaneous electrodetermination of paracetamol (PAR) and diclofenac (DIC) at trace levels. Structural and morphological characterization of the nanocomposite were carried out using suitable techniques. The modified electrode; ZIF-67/SiONPs/GONs/GCE, exhibited excellent electrocatalytic activities toward the oxidation of PAR and DIC than the bare GCE, GONs/GCE, SiONPs/GONs/GCE and ZIF-67/GCE. Through using differential pulse voltammetry, the individual and simultaneous determination of PAR and DIC were conducted by the ZIF-67/SiONPs/GONs/GCE. Under optimal conditions, it has been observed that the calibration plots for PAR and DIC exhibit linearity within the concentration ranges of 0.5-190 (PAR) and 0.5-200 µM (DIC), with detection limits of 0.29 and 0.132 µM for PAR and DIC, respectively. The ZIF-67/SiONPs/GONs/GCE shows commendable stability, reproducibility, and repeatability, and the proposed method is evaluated by individual and simultaneous determination of PAR and DIC in real samples with satisfactory results (recovery > 97%).

摘要

在本工作中，合成了一种新型纳米复合材料，其包含沸石咪唑酯骨架-67修饰的二氧化硅纳米颗粒/氧化石墨烯纳米片（ZIF-67/SiONPs/GONs），并用于制备修饰玻碳电极，以实现对痕量水平的对乙酰氨基酚（PAR）和双氯芬酸（DIC）进行单独和同时的电分析测定。使用合适的技术对该纳米复合材料进行了结构和形态表征。修饰电极ZIF-67/SiONPs/GONs/GCE对PAR和DIC氧化表现出比裸玻碳电极、GONs/GCE、SiONPs/GONs/GCE和ZIF-67/GCE优异的电催化活性。通过差分脉冲伏安法，利用ZIF-67/SiONPs/GONs/GCE对PAR和DIC进行单独和同时测定。在最佳条件下，观察到PAR和DIC的校准曲线在0.5 - 190（PAR）和0.5 - 200 μM（DIC）的浓度范围内呈线性，PAR和DIC的检测限分别为0.29和0.132 μM。ZIF-67/SiONPs/GONs/GCE表现出良好的稳定性、重现性和重复性，所提出的方法通过对实际样品中PAR和DIC进行单独和同时测定进行评估，结果令人满意（回收率>97%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/8b60aa464626/41598_2025_94178_Fig13_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/8da448cd9396/41598_2025_94178_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/8d07beee42d3/41598_2025_94178_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/6b8f38313703/41598_2025_94178_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/da14666061a5/41598_2025_94178_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/6fe28920dfb2/41598_2025_94178_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/37508fd384ae/41598_2025_94178_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/2d69eeb0c4d5/41598_2025_94178_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/3e1e56dd11a1/41598_2025_94178_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/c4bc7b1411e5/41598_2025_94178_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d24/11923285/8b60aa464626/41598_2025_94178_Fig13_HTML.jpg

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