Jiang Baosheng, Lin Ruipeng, Wang Tongyan, Wang Weikang, Lin Yuxin, Xie Manling, Hu Zhijian, Zhang Qian
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350122, China.
Laboratory Center, School of Public Health, The Major Subject of Environment and Health of Fujian Key Universities, Fujian Medical University, Fuzhou, 350122, China.
BMC Geriatr. 2025 Mar 19;25(1):188. doi: 10.1186/s12877-025-05841-9.
Organophosphate esters (OPEs) are widely used as an alternative to the brominated flame retardant polybrominated diphenyl ethers. The effects of OPEs on the cognitive abilities of older adults remain unclear.
A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey 2011-2014. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) word learning test, the CERAD word recall test, the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST). OPE metabolites with detection rates above 50% were included in the study. Weighted multiple linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models were used to examine the effects of individual and mixed exposures to OPE metabolites on cognitive function.
A total of 762 older adults were included. The weighted linear regression model revealed a positive association between Ln DPHP, Ln BDCPP, and Ln BCPP and the DSST score, while a negative association was observed between Ln DBUP and the DSST score. In the positive WQS model, the index was correlated with DSST score (β = 2.65, 95% CI: 0.40 ~ 4.90, P = 0.02), with DPHP having the highest weight. The results of BKMR analysis indicated a borderline statistical significance in the increase of DSST score when the mixture of OPEs is set to a specific 90th percentile compared to all mixture concentrations set to the median.
Overall exposure to OPE metabolites are associated with improved cognitive function in older adults in the United States. Further prospective studies with large sample sizes are needed to confirm these results.
有机磷酸酯（OPEs）被广泛用作溴化阻燃剂多溴二苯醚的替代品。OPEs对老年人认知能力的影响仍不清楚。
利用2011 - 2014年美国国家健康与营养检查调查的数据进行了一项横断面研究。使用阿尔茨海默病注册协会（CERAD）单词学习测试、CERAD单词回忆测试、动物流畅性测试（AFT）和数字符号替换测试（DSST）评估认知功能。检测率高于50%的OPE代谢物被纳入研究。采用加权多元线性回归、加权分位数和（WQS）回归以及贝叶斯核机器回归（BKMR）模型来研究个体和混合暴露于OPE代谢物对认知功能的影响。
共纳入762名老年人。加权线性回归模型显示，Ln DPHP、Ln BDCPP和Ln BCPP与DSST得分呈正相关，而Ln DBUP与DSST得分呈负相关。在正向WQS模型中，该指数与DSST得分相关（β = 2.65，95%CI：0.
