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FMRF酰胺对吗啡和剥夺诱导进食的抑制作用。

Inhibitory influences of FMRFamide on morphine- and deprivation-induced feeding.

作者信息

Kavaliers M, Hirst M, Mathers A

出版信息

Neuroendocrinology. 1985 Jun;40(6):533-5. doi: 10.1159/000124126.

DOI:10.1159/000124126
PMID:4010892
Abstract

Intracerebroventricular administration of 0.01-1.0 microgram of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) to mice reduced morphine-induced feeding. Administration of FMRFamide also inhibited feeding induced by a 24-hour period of food deprivation. These results suggest that FMRFamide or FMRFamide-like neuropeptides play an important role in the control of opioid-mediated feeding.

摘要

向小鼠脑室内注射0.01 - 1.0微克的肽FMRF酰胺（苯丙氨酸-甲硫氨酸-精氨酸-苯丙氨酸-氨基）可减少吗啡诱导的摄食。注射FMRF酰胺也可抑制24小时食物剥夺诱导的摄食。这些结果表明，FMRF酰胺或类FMRF酰胺神经肽在阿片类介导的摄食控制中起重要作用。

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Inhibitory influences of FMRFamide on morphine- and deprivation-induced feeding.FMRF酰胺对吗啡和剥夺诱导进食的抑制作用。
Neuroendocrinology. 1985 Jun;40(6):533-5. doi: 10.1159/000124126.
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Inhibitory influences of mammalian FMRFamide (Phe-Met-Arg-Phe-amide)-related peptides on nociception and morphine- and stress-induced analgesia in mice.
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PLG and FMRFamide--endogenous peptides with marked inhibitory effects on opioid-induced feeding.
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A-18-famide and F-8-famide, endogenous mammalian equivalents of the molluscan neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2), inhibit colonic bead expulsion time in mice.
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FMRFamide: an endogenous peptide with marked inhibitory effects on opioid-induced feeding behavior.FMRF酰胺：一种对阿片类药物诱导的摄食行为具有显著抑制作用的内源性肽。
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FMRFamide, a putative endogenous opiate antagonist: evidence from suppression of defeat-induced analgesia and feeding in mice.
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NPFF, a FMRF-NH2-like peptide, blocks opiate effects on ileum contractions.NPFF，一种类FMRF-NH2肽，可阻断阿片类药物对回肠收缩的作用。
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