隐花色素（CRY）在癌症中的作用：分子机制与基于生物钟的治疗策略。
The role of cryptochrome (CRY) in cancer: molecular mechanisms and clock-based therapeutic strategies.
作者信息
Zhang Shuzhao, Chen Xue, Li Jiayi, Xu An'an, Bode Ann M, Luo Xiangjian
机构信息
Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha 410078, China.
出版信息
Acta Biochim Biophys Sin (Shanghai). 2025 Mar 19;57(7):1037-1046. doi: 10.3724/abbs.2025025.
The circadian rhythm is a phenomenon in which physiological, behavioral, and biochemical processes within an organism naturally fluctuate over a period of approximately 24 hours. This phenomenon is ubiquitous in living organisms. Disruption of circadian rhythms in mammals leads to different diseases, such as cancer, and neurodegenerative and metabolic disorders. In specific tissues, numerous genes have been found to have circadian oscillations, suggesting a broad role for rhythm genes in the regulation of gene expression. This review systematically summarizes the role of cryptochromes (CRYs) in the initiation and progression of different types of cancer and discusses the relationships between clock genes and the tumor microenvironment (TME), as well as clock-based therapeutic strategies.
昼夜节律是一种现象，即生物体内部的生理、行为和生化过程会在大约24小时的周期内自然波动。这种现象在生物体内普遍存在。哺乳动物昼夜节律的破坏会导致不同的疾病，如癌症、神经退行性疾病和代谢紊乱。在特定组织中，已发现许多基因具有昼夜振荡，这表明节律基因在基因表达调控中具有广泛作用。本综述系统总结了隐花色素（CRYs）在不同类型癌症的发生和发展中的作用，并讨论了生物钟基因与肿瘤微环境（TME）之间的关系以及基于生物钟的治疗策略。
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