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昼夜节律相关因素的 PER 和 CRY 家族基因可作为肺腺癌的新型治疗靶点和预后生物标志物。

Circadian rhythm-related factors of PER and CRY family genes function as novel therapeutic targets and prognostic biomarkers in lung adenocarcinoma.

机构信息

Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

出版信息

Aging (Albany NY). 2022 Nov 16;14(22):9056-9089. doi: 10.18632/aging.204386.

DOI:10.18632/aging.204386
PMID:36385012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9740380/
Abstract

The period () and cryptochrome () families play critical roles in circadian rhythms. The imbalance of circadian factors may lead to the occurrence of cancer. Expressions of and family members decrease in various cancers. Nevertheless, expression levels, genetic variations, and molecular mechanisms of and family members in lung adenocarcinoma (LUAD) and their correlations with prognoses and immune infiltration in LUAD patients are still unclear. In this study, to identify their biological functions in LUAD development, comprehensive high-throughput techniques were applied to analyze the relationships of expressions of and family members with genetic variations, molecular mechanisms, and immune infiltration. The present results showed that transcription levels of and in LUAD were significantly downregulated. High expression levels of , , , and indicated longer overall survival. Some cancer signaling pathways were related to and family members, such as cell-cycle, histidine metabolism, and progesterone-mediated oocyte maturation pathways. Expressions of and family members significantly affected the infiltration of different immune cells. In conclusion, our findings may help better understand the molecular basis of LUAD, and provide new perspectives of and family members as novel biomarkers for LUAD.

摘要

（周期）和（隐花色素）家族在昼夜节律中起着关键作用。昼夜节律因子的失衡可能导致癌症的发生。和家族成员在各种癌症中的表达减少。然而，肺腺癌（LUAD）中 和 家族成员的表达水平、遗传变异和分子机制及其与 LUAD 患者预后和免疫浸润的相关性尚不清楚。在这项研究中，为了确定它们在 LUAD 发展中的生物学功能，应用综合高通量技术分析了 和 家族成员的表达与遗传变异、分子机制和免疫浸润的关系。目前的结果表明，LUAD 中 和 的转录水平显著下调。高表达水平的 、 、 和 预示着总生存期更长。一些癌症信号通路与 和 家族成员有关，如细胞周期、组氨酸代谢和孕激素介导的卵母细胞成熟途径。 和 家族成员的表达显著影响不同免疫细胞的浸润。总之，我们的研究结果可能有助于更好地理解 LUAD 的分子基础，并为 和 家族成员作为 LUAD 的新型生物标志物提供新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17a5/9740380/7c6797736f81/aging-14-204386-g014.jpg
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