Kase C S, Robinson R K, Stein R W, DeWitt L D, Hier D B, Harp D L, Williams J P, Caplan L R, Mohr J P
Neurology. 1985 Jul;35(7):943-8. doi: 10.1212/wnl.35.7.943.
Twenty-four patients had intracerebral hemorrhage while they were being treated with anticoagulants. Hypertension was present in 67% of the cases, head trauma was an uncommon preceding event, and simultaneous bleeding in other organs occurred in only one instance. Neurologic abnormalities progressed for several hours in 58%. Seizures occurred at onset in 12.5%. The location of the hemorrhage was as follows: cerebellum (nine cases), lobar white matter (six), basal ganglia (five), thalamus (two), and hemisphere, unspecified (two). In 61%, the hemorrhages occurred within 6 months of therapy. In 75%, the prothrombin time was beyond 1 1/2 times the control value. Mortality was 62.5%. Survivors had smaller hematomas than did patients with fatal hemorrhage.
24例患者在接受抗凝治疗时发生脑出血。67%的病例存在高血压，头部外伤是罕见的前驱事件，仅1例出现其他器官同时出血。58%的患者神经功能异常持续进展数小时。12.5%的患者起病时发生癫痫。出血部位如下：小脑（9例）、脑叶白质（6例）、基底节（5例）、丘脑（2例）和未明确的半球（2例）。61%的出血发生在治疗后6个月内。75%的患者凝血酶原时间超过对照值的1.5倍。死亡率为62.5%。幸存者的血肿比致命性出血患者的血肿小。
