Rached Roberto D, Helfenstein Thomas, Kim Angela H, Da Costa Thadeu R, Araújo Ricardo L
Physical Medicine and Rehabilitation, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BRA.
Cureus. 2025 Feb 16;17(2):e79088. doi: 10.7759/cureus.79088. eCollection 2025 Feb.
Peripheral nerve injuries, such as axonal injury of the superior gluteal nerve, are rare but debilitating complications that can occur after hip arthroplasty. This case report describes the use of adipose-derived mesenchymal stem cells (MSCs) to treat an axonal injury of the superior gluteal nerve in a 71-year-old patient. After conventional rehabilitation failed, MSC infiltration was chosen and performed with ultrasound (US) guidance. Two months later, the patient showed normalization of electromyography (EMG), indicating full nerve recovery, along with significant improvement in neuropathic pain. The patient also demonstrated a 55% increase in maximum torque and a 9% increase in power during right hip extension in isokinetic evaluation, resulting in improvement of muscle strength and functionality. This case highlights the potential of MSCs in promoting nerve regeneration, suggesting that this approach may accelerate nerve recovery and improve short-term clinical outcomes. Although the results are promising, further studies are needed to confirm the efficacy and safety of this treatment in a larger population. This integrated model of cell therapy and physical rehabilitation represents a significant advance in recovering from complex nerve injuries.
周围神经损伤，如臀上神经轴突损伤，是髋关节置换术后可能发生的罕见但使人衰弱的并发症。本病例报告描述了使用脂肪来源的间充质干细胞（MSCs）治疗一名71岁患者的臀上神经轴突损伤。在传统康复治疗失败后，选择并在超声（US）引导下进行了MSCs浸润治疗。两个月后，患者肌电图（EMG）恢复正常，表明神经完全恢复，同时神经性疼痛也有显著改善。在等速评估中，患者右髋关节伸展时最大扭矩增加了55%，力量增加了9%，肌肉力量和功能得到改善。本病例突出了MSCs在促进神经再生方面的潜力，表明这种方法可能加速神经恢复并改善短期临床结果。尽管结果很有前景，但需要进一步研究以在更大规模人群中证实这种治疗的有效性和安全性。这种细胞治疗与物理康复的综合模式代表了从复杂神经损伤中恢复的重大进展。
