脂肪源性干细胞在肩袖损伤治疗中的作用：从基础科学到临床应用
The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application.
作者信息
Mocini Fabrizio, Monteleone Andrea Stefano, Piazza Piero, Cardona Valentina, Vismara Valeria, Messinese Piermarco, Campana Vincenzo, Sircana Giuseppe, Maccauro Giulio, Saccomanno Maristella Francesca
机构信息
Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
出版信息
Orthop Rev (Pavia). 2020 Jun 26;12(Suppl 1):8682. doi: 10.4081/or.2020.8682. eCollection 2020 Jun 29.
Abstract
Over the last decade, regenerative medicine has become increasingly popular throughout the scientific community. The poor healing capacity at the tendon-bone interface makes the rotator cuff an appealing target for biologic agents. Adipose derived stem cells are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. They have been recently proposed, both in isolation and as adjuvants to existing surgical therapies, for the treatment of rotator cuff tears. Several studies have been carried out in this research field, starting from the biological characteristics of adipose derived stem cells, their preparation and culture, up to the application in the experimental field on animal models and on humans. The purpose of this study was to provide a state of the art about the current basic science and clinical literature for the effectiveness of adipose derived stem cells in the treatment of rotator cuff tears.
摘要
在过去十年中，再生医学在科学界越来越受欢迎。肌腱-骨界面的愈合能力较差，使得肩袖成为生物制剂的一个有吸引力的靶点。脂肪来源干细胞是具有自我更新和多能分化能力的间充质细胞。最近，它们已被单独提出，并作为现有手术治疗的辅助手段，用于治疗肩袖撕裂。从脂肪来源干细胞的生物学特性、制备和培养，到在动物模型和人体实验领域的应用，该研究领域已经开展了多项研究。本研究的目的是提供关于脂肪来源干细胞治疗肩袖撕裂有效性的当前基础科学和临床文献的最新情况。
相似文献
1
The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application.脂肪源性干细胞在肩袖损伤治疗中的作用：从基础科学到临床应用
Orthop Rev (Pavia). 2020 Jun 26;12(Suppl 1):8682. doi: 10.4081/or.2020.8682. eCollection 2020 Jun 29.
2
Isolation and characterization of 2 new human rotator cuff and long head of biceps tendon cells possessing stem cell-like self-renewal and multipotential differentiation capacity.分离并鉴定具有干细胞样自我更新和多向分化潜能的 2 种新型人肩袖和肱二头肌长头肌腱细胞。
Am J Sports Med. 2013 Jul;41(7):1653-64. doi: 10.1177/0363546512473572. Epub 2013 Feb 7.
3
Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears.从肩袖撕裂相关的肩组织中分离和鉴定人骨髓间充质干细胞。
Am J Sports Med. 2013 Mar;41(3):657-68. doi: 10.1177/0363546512473269. Epub 2013 Jan 31.
4
Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model.兔模型中超声引导下注射脐带血源性间充质干细胞后全层肩袖肌腱撕裂的再生
Stem Cells Transl Med. 2015 Nov;4(11):1344-51. doi: 10.5966/sctm.2015-0040. Epub 2015 Sep 14.
5
Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model.转染肌腱形成蛋白基因的骨髓间充质干细胞改善大鼠肩袖愈合。
Am J Sports Med. 2011 Jun;39(6):1282-9. doi: 10.1177/0363546510395485. Epub 2011 Feb 18.
6
Does an Injection of Adipose-Derived Mesenchymal Stem Cells Loaded in Fibrin Glue Influence Rotator Cuff Repair Outcomes? A Clinical and Magnetic Resonance Imaging Study.注射于纤维蛋白胶中的脂肪源性间充质干细胞对肩袖修复结果有影响吗？一项临床和磁共振成像研究。
Am J Sports Med. 2017 Jul;45(9):2010-2018. doi: 10.1177/0363546517702863. Epub 2017 Apr 27.
7
Reduced levels of mesenchymal stem cells at the tendon-bone interface tuberosity in patients with symptomatic rotator cuff tear.有症状的肩袖撕裂患者肌腱-骨界面结节处间充质干细胞水平降低。
Int Orthop. 2015 Jun;39(6):1219-25. doi: 10.1007/s00264-015-2724-8. Epub 2015 Mar 12.
8
The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.脂肪来源干细胞对大鼠急性和慢性巨大肩袖撕裂修复后腱止点愈合的影响。
J Shoulder Elbow Surg. 2019 Apr;28(4):654-664. doi: 10.1016/j.jse.2018.08.044. Epub 2018 Dec 4.
9
[Use of cultured human autologous bone marrow stem cells in repair of a rotator cuff tear: preliminary results of a safety study].[培养的人自体骨髓干细胞在修复肩袖撕裂中的应用：一项安全性研究的初步结果]
Acta Chir Orthop Traumatol Cech. 2015;82(3):229-34.
10
Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 2: Rotator Cuff.生物治疗运动损伤 II 智库——当前概念、未来研究和进展障碍，第 2 部分：肩袖。
Orthop J Sports Med. 2016 Mar 31;4(3):2325967116636586. doi: 10.1177/2325967116636586. eCollection 2016 Mar.
引用本文的文献
1
3D bioprinted multi-layered cell constructs with gradient core-shell interface for tendon-to-bone tissue regeneration.用于肌腱-骨组织再生的具有梯度核壳界面的3D生物打印多层细胞构建体。
Bioact Mater. 2024 Oct 11;43:471-490. doi: 10.1016/j.bioactmat.2024.10.002. eCollection 2025 Jan.
2
Mesenchymal Stem Cell Therapy for Superior Gluteal Nerve Injury Post-hip Arthroplasty: A Case Report.间充质干细胞疗法治疗髋关节置换术后臀上神经损伤：一例报告
Cureus. 2025 Feb 16;17(2):e79088. doi: 10.7759/cureus.79088. eCollection 2025 Feb.
3
Efficacy of Adipose-Derived Mesenchymal Stem Cells and Stromal Vascular Fraction Alone and Combined to Biomaterials in Tendinopathy or Tendon Injury: Systematic Review of Current Concepts.脂肪来源间充质干细胞和基质血管成分单独及联合生物材料治疗肌腱病或肌腱损伤的疗效：当前概念的系统评价。
Medicina (Kaunas). 2023 Jan 31;59(2):273. doi: 10.3390/medicina59020273.
4
Enhanced Repaired Enthesis Using Tenogenically Differentiated Adipose-Derived Stem Cells in a Murine Rotator Cuff Injury Model.在小鼠肩袖损伤模型中使用经肌腱分化的脂肪来源干细胞增强修复的肌腱附着点
Stem Cells Int. 2022 May 14;2022:1309684. doi: 10.1155/2022/1309684. eCollection 2022.
5
Clinical Application of Adipose Derived Stem Cells for the Treatment of Aseptic Non-Unions: Current Stage and Future Perspectives-Systematic Review.脂肪源性干细胞治疗无菌性骨不连的临床应用：现状与未来展望——系统评价。
Int J Mol Sci. 2022 Mar 11;23(6):3057. doi: 10.3390/ijms23063057.
本文引用的文献
1
Intratendinous Injection of Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A 2-Year Follow-Up Study.肌腱内注射间充质干细胞治疗肩袖疾病：一项为期 2 年的随访研究。
Arthroscopy. 2020 Apr;36(4):971-980. doi: 10.1016/j.arthro.2019.11.120. Epub 2019 Dec 3.
2
Exosomes Isolated From Adipose-Derived Stem Cells: A New Cell-Free Approach to Prevent the Muscle Degeneration Associated With Torn Rotator Cuffs.脂肪来源干细胞衍生的外泌体：一种防止与撕裂肩袖相关的肌肉退化的新型无细胞方法。
Am J Sports Med. 2019 Nov;47(13):3247-3255. doi: 10.1177/0363546519876323. Epub 2019 Sep 27.
3
Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of acromioclavicular joint osteoarthritis.自体脂肪间充质干细胞治疗肩锁关节骨关节炎的疗效
BMJ Case Rep. 2019 Feb 27;12(2):e227865. doi: 10.1136/bcr-2018-227865.
4
The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.脂肪来源干细胞对大鼠急性和慢性巨大肩袖撕裂修复后腱止点愈合的影响。
J Shoulder Elbow Surg. 2019 Apr;28(4):654-664. doi: 10.1016/j.jse.2018.08.044. Epub 2018 Dec 4.
5
Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial.自体脂肪来源间充质干细胞肌腱内注射治疗肩袖疾病：一项首次人体试验。
Stem Cells. 2018 Sep;36(9):1441-1450. doi: 10.1002/stem.2855. Epub 2018 Jul 16.
6
What happens to patients when we do not repair their cuff tears? Five-year rotator cuff quality-of-life index outcomes following nonoperative treatment of patients with full-thickness rotator cuff tears.当我们不修复肩袖撕裂时，患者会发生什么？全层肩袖撕裂非手术治疗 5 年后的肩袖质量生活指数结果。
J Shoulder Elbow Surg. 2018 Mar;27(3):444-448. doi: 10.1016/j.jse.2017.10.009.
7
Clinical use of adipose-derived stem cells: European legislative issues.脂肪来源干细胞的临床应用：欧洲立法问题。
Ann Med Surg (Lond). 2017 Nov 10;24:61-64. doi: 10.1016/j.amsu.2017.11.002. eCollection 2017 Dec.
8
Maximizing non-enzymatic methods for harvesting adipose-derived stem from lipoaspirate: technical considerations and clinical implications for regenerative surgery.最大限度地利用非酶方法从脂肪抽吸物中收获脂肪来源的干细胞：再生手术的技术考虑和临床意义。
Sci Rep. 2017 Aug 30;7(1):10015. doi: 10.1038/s41598-017-10710-6.
9
Does an Injection of Adipose-Derived Mesenchymal Stem Cells Loaded in Fibrin Glue Influence Rotator Cuff Repair Outcomes? A Clinical and Magnetic Resonance Imaging Study.注射于纤维蛋白胶中的脂肪源性间充质干细胞对肩袖修复结果有影响吗？一项临床和磁共振成像研究。
Am J Sports Med. 2017 Jul;45(9):2010-2018. doi: 10.1177/0363546517702863. Epub 2017 Apr 27.
10
Longitudinal Long-term Magnetic Resonance Imaging and Clinical Follow-up After Single-Row Arthroscopic Rotator Cuff Repair: Clinical Superiority of Structural Tendon Integrity.单排关节镜下肩袖修补术后的纵向长期磁共振成像及临床随访：结构肌腱完整性的临床优势
Am J Sports Med. 2017 May;45(6):1283-1288. doi: 10.1177/0363546517689873. Epub 2017 Mar 8.
Zotero 插件