Mocini Fabrizio, Monteleone Andrea Stefano, Piazza Piero, Cardona Valentina, Vismara Valeria, Messinese Piermarco, Campana Vincenzo, Sircana Giuseppe, Maccauro Giulio, Saccomanno Maristella Francesca
Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
Orthop Rev (Pavia). 2020 Jun 26;12(Suppl 1):8682. doi: 10.4081/or.2020.8682. eCollection 2020 Jun 29.
Over the last decade, regenerative medicine has become increasingly popular throughout the scientific community. The poor healing capacity at the tendon-bone interface makes the rotator cuff an appealing target for biologic agents. Adipose derived stem cells are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. They have been recently proposed, both in isolation and as adjuvants to existing surgical therapies, for the treatment of rotator cuff tears. Several studies have been carried out in this research field, starting from the biological characteristics of adipose derived stem cells, their preparation and culture, up to the application in the experimental field on animal models and on humans. The purpose of this study was to provide a state of the art about the current basic science and clinical literature for the effectiveness of adipose derived stem cells in the treatment of rotator cuff tears.
在过去十年中，再生医学在科学界越来越受欢迎。肌腱-骨界面的愈合能力较差，使得肩袖成为生物制剂的一个有吸引力的靶点。脂肪来源干细胞是具有自我更新和多能分化能力的间充质细胞。最近，它们已被单独提出，并作为现有手术治疗的辅助手段，用于治疗肩袖撕裂。从脂肪来源干细胞的生物学特性、制备和培养，到在动物模型和人体实验领域的应用，该研究领域已经开展了多项研究。本研究的目的是提供关于脂肪来源干细胞治疗肩袖撕裂有效性的当前基础科学和临床文献的最新情况。
