Su Feng-Chieh, Wei Yi-Chia, Sun Chiao-Yin, Hsu Heng-Jung, Lee Chin-Chan, Chen Yih-Ting, Pan Heng-Chih, Hsu Cheng-Kai, Liu Yun-An, Chen Chun-Yu
Department of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Toxics. 2024 Jul 17;12(7):514. doi: 10.3390/toxics12070514.
Endocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.
The Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants. From this initial cohort, 120 individuals were selected based on their EDC exposure scores for detailed analysis. Among these, 67 participants aged 55 years or older were further chosen to undergo cognitive impairment assessments using the Ascertain Dementia-8 (AD-8) questionnaire.
These 67 older participants did not significantly differ in age, albuminuria, or estimated glomerular filtration rate compared to those with lower impairment scores. This study revealed that mono-(2-ethylhexyl) phthalate (MEHP) levels (8.511 vs. 6.432 µg/g creatinine, = 0.038) were associated with greater risk of cognitive impairment (AD-8 ≥ 2). Statistical models adjusting for age, gender, and diabetes indicated that MEHP levels positively correlated with AD-8 scores, achieving statistical significance in more comprehensive models (β ± SE: 0.160 ± 0.076, = 0.042). Logistic regression analysis underscored a significant positive association between high MEHP levels and higher AD-8 scores (odds ratio: 1.217, = 0.006). Receiver operating characteristic curves highlighted the association of high MEHP levels and EDC exposure scores for significant cognitive impairment, with areas under the curve of 66.3% and 66.6%, respectively.
Exposure to EDCs, specifically di-(2-ethylhexyl) phthalate, the precursor to MEHP, may be associated with neurocognitive impairment in middle-aged and older adults.
内分泌干扰化学物质（EDCs）在日常环境中普遍存在。这些化学物质以及与EDC相关的生活方式和饮食习惯对神经认知功能的影响尚未得到充分了解。
长庚社区医学研究中心进行了一项横断面研究，涉及887名参与者。从这个初始队列中，根据他们的EDC暴露分数选择了120个人进行详细分析。其中，进一步选择了67名55岁及以上的参与者，使用简易痴呆筛查量表（AD-8）问卷进行认知障碍评估。
与损伤分数较低的参与者相比，这67名老年参与者在年龄、蛋白尿或估计肾小球滤过率方面没有显著差异。这项研究表明，邻苯二甲酸单（2-乙基己基）酯（MEHP）水平（8.511对6.432μg/g肌酐，P = 0.038）与认知障碍（AD-8≥2）的更高风险相关。调整年龄、性别和糖尿病的统计模型表明，MEHP水平与AD-8分数呈正相关，在更全面的模型中具有统计学意义（β±SE：0.160±0.076，P = 0.042）。逻辑回归分析强调了高MEHP水平与较高AD-8分数之间的显著正相关（优势比：1.217，P = 0.006）。受试者工作特征曲线突出了高MEHP水平和EDC暴露分数与显著认知障碍的关联，曲线下面积分别为66.3%和66.6%。
接触EDCs，特别是MEHP的前体邻苯二甲酸二（2-乙基己基）酯，可能与中老年人群的神经认知障碍有关。
