Chen Meiqin, Chen Xiguo, Wang Shun, Lei Dan, Peng Chunxian
Department of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, People's Hospital, Quzhou, People's Republic of China.
Department of Electromechanical Engineering, Quzhou College of Technology, Quzhou, People's Republic of China.
Int J Womens Health. 2025 Mar 14;17:785-791. doi: 10.2147/IJWH.S505065. eCollection 2025.
Hepatic angiosarcoma is an extremely rare, uncontrollable tumor with strong invasion, high mortality rate, and extremely poor prognosis. There is first report on hepatic angiosarcoma accompanied by eosinophilia.
A woman with a chief complaint of poor appetite for about 3 months presented to a local hospital with a liver mass. Laboratory examination revealed a significant increase in eosinophils count was 9.58% in the serum. Abdominal MRI revealed multiple focal high-density lesions in the liver and spleen, and cranial MRI revealed multiple high-density shadows in the skull. Laparoscopic biopsy revealed a hepatic angiosarcoma and targeted treatment with Anlotinib was performed. Two months later, the patient died of splenic rupture and bleeding.
Hepatic angiosarcoma often has no specific clinical manifestations, and we found that this case can lead to an increase in eosinophils, which is worth the attention of clinical physicians.
肝血管肉瘤是一种极其罕见、难以控制的肿瘤，具有较强的侵袭性、高死亡率和极差的预后。首次报道了伴有嗜酸性粒细胞增多的肝血管肉瘤。
一名以食欲减退约3个月为主诉的女性因肝脏肿块就诊于当地医院。实验室检查显示血清嗜酸性粒细胞计数显著增加，为9.58%。腹部磁共振成像（MRI）显示肝脏和脾脏有多个局灶性高密度病变，头颅MRI显示颅骨有多个高密度阴影。腹腔镜活检显示为肝血管肉瘤，并采用安罗替尼进行靶向治疗。两个月后，患者死于脾破裂出血。
肝血管肉瘤通常无特异性临床表现，我们发现该病例可导致嗜酸性粒细胞增多，值得临床医生关注。
