Wang Huiquan, Zhang Jiafeng, Ren Hefei, Chen Lei, Ren Jigang, Liu Chang, Wu Hongkun, Zhou Lin
Department of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Front Oncol. 2025 Mar 5;15:1531928. doi: 10.3389/fonc.2025.1531928. eCollection 2025.
Multiple myeloma (MM) is a complex hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. Emerging studies have emphasized the importance of lipid metabolism, which is closely associated with the survival, proliferation, and drug resistance of tumor cells. The hypoxic environment in the bone marrow (BM) contributes to metabolic reprogramming in MM cells, including alterations in metabolite levels, changes in metabolic enzyme activity, and metabolic shifts. Cancer cells possess the ability to adapt their metabolism in order to fulfill their continuously increasing energy demands. In this review, we will discuss the alterations in lipid metabolism during the development of MM, and their reciprocal interactions with the tumor microenvironment.
多发性骨髓瘤（MM）是一种复杂的血液系统恶性肿瘤，其特征是骨髓中浆细胞的克隆性扩增。新兴研究强调了脂质代谢的重要性，脂质代谢与肿瘤细胞的存活、增殖和耐药性密切相关。骨髓（BM）中的缺氧环境有助于MM细胞的代谢重编程，包括代谢物水平的改变、代谢酶活性的变化和代谢转变。癌细胞具有调整其代谢的能力，以满足其不断增加的能量需求。在本综述中，我们将讨论MM发生发展过程中脂质代谢的改变，以及它们与肿瘤微环境的相互作用。
