Dehghani Elaheh, Beba Mohammad, Danandeh Khashayar, Memari Amirhossein, Ershadmanesh Mohamad Javad, Rasoulian Pegah, Danandeh Arshiya, Djafarian Kurosh
Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ann Med Surg (Lond). 2025 Jan 21;87(2):880-890. doi: 10.1097/MS9.0000000000002914. eCollection 2025 Feb.
This systematic review and meta-analysis quantified the effect of tart cherry juice (TCJ) supplementation on exercise-induced muscle damage (EIMD). Evidence supported TCJ's beneficial effects on muscular function and inflammatory biomarkers interleukin (IL)-6 and IL-8.
PubMed, Scopus, and Web of Science were searched up to January 2024. Risk of bias was assessed using RevMan® software. Mean differences and 95% confidence intervals (CIs) of maximal voluntary isometric contraction (MVIC), inflammatory markers, creatine kinase (CK), and visual analog scale (VAS) score were pooled using fixed- or random-effect models. Heterogeneity was assessed using Chi-square or statistics.
Ten trials were included in the analysis. TCJ supplementation significantly improved MVIC [weighted mean difference (WMD) = 9.13%, 95% CI (6.42-11.84), = 62.3%] and decreased IL-6 [WMD = -0.4 pg/ml, 95% CI (-0.68 to -0.11), = 62.2%] and IL-8 [WMD = -0.3 pg/ml, 95% CI (-0.6 to -0.0), = 46.3%]. No significant changes were found in CK, C-reactive protein, IL-1β, tumor necrosis factor-alpha, or VAS score. Dose-response analysis revealed a significant non-linear association between daily TCJ dose and MVIC effect size.
TCJ supplementation may improve muscle function and some inflammatory biomarkers in EIMD. Further high-quality studies with larger sample sizes are needed to determine TCJ's long-term effects.
本系统评价和荟萃分析量化了酸樱桃汁（TCJ）补充剂对运动诱导的肌肉损伤（EIMD）的影响。有证据支持TCJ对肌肉功能以及炎症生物标志物白细胞介素（IL）-6和IL-8具有有益作用。
检索了截至2024年1月的PubMed、Scopus和Web of Science数据库。使用RevMan®软件评估偏倚风险。使用固定效应或随机效应模型汇总最大自主等长收缩（MVIC）、炎症标志物、肌酸激酶（CK）和视觉模拟量表（VAS）评分的均值差异和95%置信区间（CI）。使用卡方检验或 统计量评估异质性。
分析纳入了10项试验。补充TCJ显著改善了MVIC[加权均值差（WMD）=9.13%，95%CI（6.42 - 11.84）， =62.3%]，并降低了IL-6[WMD=-0.4 pg/ml，95%CI（-0.68至-0.11）， =62.2%]和IL-8[WMD=-0.3 pg/ml，95%CI（-0.6至-0.0）， =46.3%]。CK、C反应蛋白、IL-1β、肿瘤坏死因子-α或VAS评分未发现显著变化。剂量反应分析显示，每日TCJ剂量与MVIC效应大小之间存在显著的非线性关联。
补充TCJ可能改善EIMD中的肌肉功能和一些炎症生物标志物。需要进一步开展更大样本量的高质量研究来确定TCJ的长期影响。
