Beak Ji Yun, Kang Ki Sung, Lee Ah Young, Kim Hyun Young
Department of Food Science, Gyeongsang National University, Jinju, 52725 Korea.
College of Korean Medicine, Gachon University, Seongnam, 13120 Korea.
Food Sci Biotechnol. 2025 Jan 6;34(6):1467-1477. doi: 10.1007/s10068-024-01766-y. eCollection 2025 Apr.
This study investigated the therapeutic efficacy of chicken feet combined with traditional herbal medicines widely used in Korea, Seeman and Oliver, in osteoarthritis (OA) progression. In this study, rats were administered chicken feet, , and mixture extracts (CAEM, 300 mg/kg) for 24 days after the monosodium iodoacetate (MIA) injection into the knee joints. CAEM significantly reduced the weight-bearing loss of the hind limb. In addition, Micro-CT imaging and histopathological analysis indicated that CAEM inhibited MIA-induced cartilage destruction, as evidenced by increased proteoglycan and decreased cartilage erosion. Western blot analysis showed that CAEM suppressed the inflammatory responses induced by MIA in knee cartilage tissue by regulating MAPK and NF-κB signaling pathways. Furthermore, CAEM treatment showed efficacy in suppressing the acetic acid-induced writhing response in mice. Therefore, CAEM may be helpful in relieving pain, alleviating cartilage degeneration, and inhibiting inflammatory responses in OA.
本研究调查了鸡脚与韩国广泛使用的传统草药Seeman和Oliver联合使用对骨关节炎（OA）进展的治疗效果。在本研究中，向大鼠膝关节注射碘乙酸钠（MIA）后，给予大鼠鸡脚、Seeman和Oliver混合提取物（CAEM，300mg/kg），持续24天。CAEM显著降低了后肢的负重损失。此外，显微CT成像和组织病理学分析表明，CAEM抑制了MIA诱导的软骨破坏，蛋白聚糖增加和软骨侵蚀减少证明了这一点。蛋白质印迹分析表明，CAEM通过调节MAPK和NF-κB信号通路抑制MIA诱导的膝关节软骨组织炎症反应。此外，CAEM治疗在抑制小鼠乙酸诱导的扭体反应方面显示出效果。因此，CAEM可能有助于缓解OA中的疼痛、减轻软骨退变并抑制炎症反应。
